阴式手术与开腹手术对子宫良性肿瘤患者炎性应激反应、盆底功能及性生活质量的影响  

Effects of Vaginal and Open Surgery on Inflammatory Stress Response,Pelvic Floor Function and Sexual Quality of Life in Patients with Uterine Benign Tumor

作　　者：张召菊 唐桂娥[1] 高兰翠 桑学梅[2] 杜丹丽[3] 卫兵[4] ZHANG Zhao-ju;TANG Gui-e;GAO Lan-cui;SANG Xue-mei;DU Dan-li;WEI Bing(Department of Obstetrics and Gynecology,Wanbei Coal Power Group General HospitalThe Third Affiliated Hlospital of Bengbu Medical College,Suzhou,Anhui,2.34000,China;Department of Gynaecology,Wanbei Coal Power Group General Hospital/The Third Affiliated Hospital of Bengbu Medical College,Suzhou,Anhui,234000,China;Department of Obstetrics and Gynecology.The First Affiliated Hospital of Bengbu Medical College,Bengbu,Anhui,233004,China;Department of Obstetrics and Gynecology,The Second Afiated Hospital of Anhui MedicalUniversity,Hefei,Anhui,2.30601,China)

机构地区：[1]皖北煤电集团总医院/蚌埠医学院第三附属医院妇产科,安徽宿州234000 [2]皖北煤电集团总医院/蚌埠医学院第三附属医院妇科,安徽宿州234000 [3]蚌埠医学院第一附属医院妇产科,安徽蚌埠233004 [4]安徽医科大学第二附属医院妇产科,安徽合肥230601

出　　处：《现代生物医学进展》2021年第7期1279-1282,共4页Progress in Modern Biomedicine

基　　金：国家自然科学基金项目(81101548);安徽省公益性研究联动计划项目(1604f0705031)。

摘　　要：目的:探讨阴式手术与开腹手术对子宫良性肿瘤患者盆底功能、炎性应激反应及性生活质量的影响。方法:回顾性分析我院自2017年3月~2019年1月期间收治的子宫良性肿瘤患者78例的临床资料,上述患者根据手术方案的不同分为A组(n=38,给予开腹手术治疗)和B组(n=40,给予阴式手术治疗),对比两组患者围术期指标、炎性应激指标[白介素-6(IL-6)、C反应蛋白(CRP)、皮质醇(Cor)]、盆底功能障碍发生率、并发症发生率及性生活质量。结果:B组术后排气时间、手术时间、住院时间、术后下床时间短于A组,术中出血量少于A组(P<0.05)。两组术后2 d的IL-6、CRP、Cor均升高,但B组低于A组(P<0.05)。B组患者盆底功能障碍发生率为12.50%(5/40),低于A组的36.84%(14/38)(P<0.05)。两组患者术后1年女性性功能指数量表(FSFI)评分均较术前增加,且B组高于A组(P<0.05)。B组术后并发症发生率低于A组(P<0.05)。结论:与开腹手术相比,阴式手术应用于子宫良性肿瘤患者,可有效改善围术期指标、炎性应激反应、盆底功能及性生活质量,减少并发症发生率。Objective:To investigate the Effects of vaginal and open surgery on pelvic floor function,inflammatory stress response and sexual quality of life in patients with uterine benign tumor.Methods:The clinical data of 78 patients with uterine benign tumor from March 2017 to January 2019 were analyzed retrospectively,the patients were divided into group A(n=38,treatment by open surgery)and group B(n=40,treatment by vaginal surgery)according to the different operative plans,the indexes of perioperative period,inflammatory stress indexes[Interleukin-6(IL-6),C-reactive protein(CRP),Cortisol(Cor)],pelvic floor dysfunction,complications and sexual quality of life were compared between the two groups.Results:The time of exhaust,operation,hospitalization and getting out of bed in group B were shorter than that in group A,and the amount of bleeding was less than that in group A(P<0.05).The levels of IL-6,CRP and cor were all increased in two groups,but the level in group B was lower than that in group A(P<0.05).The incidence of pelvic floor dysfunction in group B was 12.50%(5/40),lower than 36.84%(14/38)in group A(P<0.05).The score of Female sexual function index scale(FSFI)in the two groups was higher than that before operation,and the score in group B was higher than that in group A(P<0.05).The incidence of postoperative complications in group B was lower than that in group A(P<0.05).Conclusion:Compared with laparotomy,vaginal surgery can effectively improve the perioperative indicators,inflammatory stress response,pelvic floor function and sexual quality of life,and reduce the incidence of complications.

关 键 词：阴式手术 开腹手术 子宫良性肿瘤 炎性应激反应 盆底功能 

分 类 号：R713.4[医药卫生—妇产科学] R711.74[医药卫生—临床医学]