短疗程小剂量抗凝治疗胎儿生长受限伴抗心磷脂抗体阳性的价值分析  

Analysis of the value of short course and low dose anticoagulation in the treatment of fetal growth restriction with positive anticardiolipin antibody

作　　者：秦昌红 Qin Changhong(The Maternal and Child Health Hospital of Linyi City,Shandong Linyi 276000)

机构地区：[1]临沂市妇幼保健院,山东临沂276000

出　　处：《中国社区医师》2021年第14期81-82,共2页Chinese Community Doctors

摘　　要：目的:分析短疗程小剂量抗凝治疗胎儿生长受限伴抗心磷脂抗体阳性的价值。方法:2019年1月-2020年1月收治胎儿生长受限伴抗心磷脂抗体阳性孕妇70例,随机分为两组,各35例。对照组给予常规药物治疗;观察组在常规药物基础上增加短疗程小剂量抗凝。比较两组孕妇凝血功能、胎儿脐血流情况、头围和腹围水平。结果:观察组孕妇治疗后凝血功能活化部分凝血活酶时间(APTT)、凝血酶原时间(PT)水平均显著高于对照组,D-二聚体、纤维蛋白原(FIB)水平显著均低于对照组,差异有统计学意义(P<0.05);观察组胎儿脐血流搏动指数(PI)和阻力指数(RI)水平均显著低于对照组,头围和腹围水平均显著高于对照组,差异有统计学意义(P<0.05)。结论:常规药物联合短疗程小剂量抗凝对于胎儿生长受限伴抗心磷脂抗体阳性的治疗效果确切,可有效改善孕妇凝血功能、胎儿脐血流情况及头围和腹围水平,改善胎儿生长受限。Objective:To explore the value of short course and low dose anticoagulation in the treatment of fetal growth restriction with positive anticardiolipin antibody.Methods:From January 2019 to January 2020,70 pregnant women with fetal growth restriction and anticardiolipin antibody positive were selected and randomly divided into two groups with 35 cases in each group.The control group was given conventional drug treatment.The observation group was given short course of low-dose anticoagulation on the basis of conventional drugs.We compared the coagulation function,fetal umbilical blood flow,head circumference and abdominal circumference between the two groups.Results:In the observation group,after treatment,the levels of APTT and PT were significantly higher than those in the control group,and the levels of D-dimer and FIB were significantly lower than those in the control group,the difference was statistically significant(P<0.05).In the observation group,the levels of PI and RI of fetal umbilical blood flow were significantly lower than those in the control group,and the levels of head circumference and abdominal circumference were significantly higher than those in the control group,the difference was statistically significant(P<0.05).Conclusion:The treatment effect of conventional drugs combined with short course of low-dose anticoagulation for fetal growth restriction with anticardiolipin antibody positive is exact,it can effectively improve the coagulation function of pregnant women,fetal umbilical blood flow,head circumference and abdominal circumference,and improve fetal growth restriction.

关 键 词：短疗程小剂量抗凝治疗 胎儿生长受限 抗心磷脂抗体阳性 价值 

分 类 号：R714.5[医药卫生—妇产科学]