超重/肥胖对反复喘息婴幼儿潮气肺功能的影响  

Effects of overweight and obesity on tidal lung function of infants with recurrent wheezing

作　　者：周真[1] 李丽云[1] 谭艳芳[1] 郭素华[1] 林英[1] 赵慧[1] 李增清[1] ZHOU Zhen;LI Li-yun;TAN Yan-fang;GUO Su-hua;LIN Ying;ZHAO Hui;LI Zeng-qing(Pediatric Department,Guangdong Women and Children Hospital,Guangzhou,Guangdong 511400,China)

机构地区：[1]广东省妇幼保健院儿科,广东广州511400

出　　处：《中国儿童保健杂志》2021年第4期443-446,共4页Chinese Journal of Child Health Care

摘　　要：目的分析超重/肥胖对反复喘息婴幼儿潮气肺功能的影响,为哮喘的预防和管理奠定基础。方法选择在广东省妇幼保健院儿童呼吸科就诊的100例0~3岁反复喘息的急性发作期患儿为研究对象,按体重指数(BMI)分为喘息非超重组70例、喘息超重/肥胖组30例;选择80例0~3岁无呼吸系统疾病婴幼儿为对照组,其中非超重组50例,超重/肥胖组30例。测定各组受试患儿潮气呼吸流量-容积曲线(TBFV),记录各参数并进行比较。结果喘息非超重组与对照非超重组比较,达峰时间比(TPTEF/TE)、达峰容积比(VPTEF/VE)、吸呼比(TI∶TE)、呼出75%潮气量时的呼气流速/呼气峰流速(25/PF)均明显下降(t=8.518、7.767、3.142、7.860,P<0.05);呼气峰流速(PTEF)、呼出25%潮气量时的呼气流量(TEF75)显著增加(t=6.728、8.540,P<0.05)。分别在对照组、喘息组中,与非超重儿童肺功能参数相比,超重/肥胖儿童仅潮气量(VT/kg)显著下降(t=2.872、3.048,P<0.05)。结论超重/肥胖影响婴幼儿肺功能潮气量(VT/kg),但不影响气道阻塞的指标。Objective To investigate the effect of overweight and obesity on tidal lung function of infants with recurrent wheezing,in order to provide evidence for the prevention and control of asthma.Methods A total of 100 children aged 0 to 3 years with recurrent wheezing were selected in this study from Child Respiratory Department in Guangdong Women and Children Hospital.According to body mass index(BMI),wheezing children were divided into non-overweight group(n=70)and overweight/obesity group(n=30).And 80 children aged 0 to 3 years without respiratory diseases were selected as control group and divided into non-overweight group(n=50)and overweight/obesity group(n=30)according to BMI.The tidal breathing parameters and flow-volume loop of infants in each group were recorded and compared.Results The values of time to peak tidal expiratory flow as a proportion of expiratory time(TPTEF/TE),volume to peak expiratory flow as a proportion of exhaled volume(VPTEF/VE),inspiratory time/expiratory time(TI∶TE),tidal expiratory flow when 25%of tidal volune remain in the lung/peak tidal expiratory flow(25/PF)of the wheezing infants with non-overweight significantly decreased compared with the control group without wheezing(t=8.518,7.767,3.142,7.860,P<0.05),while peak tidal expiratory flow(PTEF),tidal expiratory flow when 75% of tidal volume remains in the lung(TEF75)increased(t=6.728,8.540,P<0.05).In the control group and the wheezing group,compared with the non-overweight infants,tidal volume/kg(VT/kg)of infants with overweight and obesity decreased(t=2.872,3.048,P<0.05).Conclusion Overweight and obesity have impacts on VT/kg of tidal lung function,but did not affect airway obstruction indicators.

关 键 词：超重/肥胖 潮气肺功能 反复喘息 幼儿 

分 类 号：R725.6[医药卫生—儿科]