牛黄清瘟饮治疗乙型肝炎相关慢加急性肝衰竭(肝瘟)前期(热毒血瘀证)临床疗效及对凝血功能的影响  

Clinical Effects of Using Niuhuang Qingwen Drink in the Treatment of Hepatitis B-related Chronic and Acute Liver Failure (Liver Fever) and Its Influnce on Coagulation Function

作　　者：刘勇[1] 周彪 LIU Yong;ZHOU Biao(Department of Hepatology,Chongqing Hospital of Traditional Chinese Medicine,Chongqing 400021,China)

机构地区：[1]重庆市中医院肝病科,重庆400021

出　　处：《四川中医》2021年第3期129-132,共4页Journal of Sichuan of Traditional Chinese Medicine

基　　金：重庆市卫生计生委中医药科技项目(牛黄清瘟饮治疗乙型肝炎相关慢加急性肝衰竭,编号:ZY201702008)。

摘　　要：目的:观察牛黄清瘟饮治疗乙型肝炎相关慢加急性肝衰竭(肝瘟)前期(热毒血瘀证)临床效果及其凝血功能的影响。方法:选取2017年7月~2020年3月我科乙型肝炎相关慢加急性肝衰竭(肝瘟)前期(热毒血瘀证)患者60例作为研究对象,随机分为对照组(n=30)和观察组(n=30)。对照组予西药基础治疗药物,观察组在对照组的基础上予牛黄清瘟饮,疗程均为12周。观察并比较患者入院前、治疗12周后的肝功能:丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST);患者入院前、治疗12周后的凝血功能:凝血酶原时间(PT)、国际标准化比值(INR)、纤维蛋白原(FIB);临床疗效。结果:两组治疗后的ALT、AST均显著低于治疗前,且观察组显著低于对照组,差异有统计学意义(P<0.05)。两组治疗后的PT、INR均显著小于治疗前,且观察组显著小于对照组;两组治疗后的FIB高于治疗前,观察组高于对照组,差异有统计学意义(P<0.05)。观察组治疗总有效率(93.33%)显著高于对照组(80.0%),差异有统计学意义(P<0.05)。结论:牛黄清温饮治疗乙型肝炎相关慢加急性肝衰竭前期,可切实提高临床疗效,有效改善患者的肝功能和凝血状态,促进恢复,值得临床推广。Objective: To investigate the clinical effect and coagulation function of using Niuhuang Qingwen Drink in treating hepatitis B-related chronic plus acute liver failure(hepatic distemper).Methods: From July 2017 to March 2020,60 patients with hepatitis B related chronic plus acute liver failure(liver blast) pre-stage(heat toxin and blood stasis syndrome) were randomly divided into controlled group(n=30) and observation group(n=30).The controlled group was given basic medicine of western medicine, and the observation group was given Niuhuang Qingwen Drink on the basis of the controlled group, the course of treatment was 12 weeks.Observed and compared the liver function of the two groups of patients before admission and 12 weeks after treatment: alanine aminotransferase(ALT),aspartate aminotransferase(AST);before admission, coagulation function after 12 weeks of treatment: prothrombin time(PT),international normalized ratio(INR),fibrinogen(FIB);clinical efficacy.Results: The ALT,AST of the two groups was significantly lower than that of the controlled group(P<0.05).The PT,INR of the two groups after treatment was significantly smaller than that before treatment, and the observation group was significantly smaller than that of the controlled group, the FIB of the two groups after treatment was higher than that of the controlled group before treatment, and the difference was statistically significant(P<0.05).The total effective rate of treatment in the observation group(93.33%) was significantly higher than that in the controlled group(80.0%),and the difference was statistically significant(P<0.05).Conclusion: Niuhuang Qingwen Drink can improve the clinical effect, improve the liver function and coagulation status, and promote the recovery, which is worthy of clinical promotion.

关 键 词：牛黄清瘟饮 乙型肝炎相关慢加急性肝衰竭 前期 临床效果 凝血功能 

分 类 号：R512.62[医药卫生—内科学]