2015—2020年沈阳市单中心神经外科手术患者抗菌药物应用调查  

Application of antibacterial drugs in neurosurgery patients in Shenyang city, 2015–2020: a retrospective single-center study

作　　者：尹昱[1] 宫建[2] 李景姝[1] 万功山[3] 冯春青[3] 郑刚[3] YIN Yu;GONG Jian;LI Jing-shu(Department of Critical Care Medicine,The Second Affiliated Hospital of Shenyang Medical College,Shenyang,Liaoning Province 110030,China;不详)

机构地区：[1]沈阳医学院附属第二医院重症医学科,沈阳110030 [2]沈阳药科大学药物流行病与临床药物评价课题组 [3]沈阳医学院附属中心医院

出　　处：《中国公共卫生》2021年第3期568-569,共2页Chinese Journal of Public Health

摘　　要：目的探讨神经外科手术患者抗菌药物应用的药物流行病学特征,并进行合理性评价。方法以真实世界研究的方法,采集沈阳市某三级甲等医院2015年1月—2020年1月神经外科1 446例手术患者病历信息,以《抗菌药物应用时间调查表》分析抗菌药物的应用时机。结果 1 446例神经外科手术患者中,Ⅰ类切口852例,Ⅱ类切口594例,抗菌药物使用率为100%,合计使用5 152例次;抗菌药物应用的适应证合理性为83.20%(1 203/1 446),手术前使用的合理性为92.19%(1 333/1 446),手术中追加使用的合理性为92.95%(1 344/1 446),手术后使用的合理性为90.25%(1 305/1 446);合计382例次(7.41%,382/5 152)患者用药时间不合理。结论抗菌药物合理使用是需要持续关注的最重要的公共卫生问题之一,把控预防性使用抗菌药物的用药时机有助于提高抗菌药物的合理用药水平。Objective To describe pharmacoepidemiological characteristics of antibacterial drug application and to evaluate the rationality of antibiotics use among inpatients with neurosurgery operation. Methods Real-world study design was adopted in the study. With a self-designed questionnaire on application of antibacterial drug application and from medical records, we collected relevant information on 1 446 inpatients with neurosurgery operations in a grade A tertiary hospital in Shenyang city during a period from January 2015 to January 2020. The rationality of antibiotics use was assessed based on the national guideline and expert consensus for clinical antibiotics application. Results All the inpatients, including852 and 594 with type I and II surgical incision in the operations, had operation-related antibiotics treatment and the total times of antibacterial drug application was 5 152 case-times. The rational proportion of antibacterial drug application was83.20%(1 203 inpatients) for right indication, 92.19%(1 333) for treatment before operation, 92.95%(1 344) for additional use during operation, and 90.25%(1 305) for treatment after operation. Totally 382 case-times of antibiotics application were irrational use in terms of medication time. Conclusion Medication time for antibacterial drug application needs to be improved for promoting rational use of antibiotics among inpatients with neurosurgery operation.

关 键 词：真实世界研究 头孢菌素 临床药物评价 合理用药 

分 类 号：R181.3—5[医药卫生—流行病学]