脑缺血后神经元自噬与凋亡机制及中药干预作用的研究进展  

Review of the Mechanism of Neuronal Autophagy and Apoptosis and the Intervention of Traditional Chinese Medicine After Cerebral Ischemia

作　　者：曹慧 徐立[1] 宋文婷[1] CAO Hui;XU Li;SONG Wenting(Institute of Basic Medical Sciences of Xiyuan Hospital,China Academy of Chinese Medical Sciences,Beijing Key Laboratory of Pharmacology of Chinese Materia Medica,Beijing 100091,China)

机构地区：[1]中国中医科学院西苑医院基础医学研究所,北京市中药药理重点实验室,北京100091

出　　处：《中药新药与临床药理》2021年第3期441-448,共8页Traditional Chinese Drug Research and Clinical Pharmacology

基　　金：国家自然科学基金青年项目(81603617);中央级公益性科研院所基本科研业务费专项资金资助项目(ZZ13-YQ-007)。

摘　　要：脑缺血是一种常见的脑血管疾病,致残、致死率高,导致严重的经济和社会负担。缺血诱导的细胞自噬失调及凋亡参与了脑缺血引发的神经损伤。中药具有多成分、多靶点的优势,可作用于脑缺血后神经损伤的不同阶段。已发现多数中药活性成分可通过调控自噬及凋亡而发挥脑保护作用。该文综述了脑缺血后细胞异常自噬与凋亡的分子生物学基础及中药对其靶点和通路的作用,可为脑缺血后神经元的保护提供治疗思路。Cerebral ischemia is a common cerebrovascular disease with a high rate of disability and mortality,resulting a heavy economic and social burden.Studies have suggested that dysregulation of autophagy and excessive apoptosis of neurons are responsible for neurological damage caused by cerebral ischemia.Traditional Chinese medicine has the advantage of multi-component and multi-target,and plays its role in different stages of cerebral ischemia.It has been found that most of the active components of traditional Chinese medicine can play a cerebral protective role by regulating autophagy and apoptosis.This article reviews the molecular biological basis of abnormal autophagy and apoptosis after cerebral ischemia and the effects of traditional Chinese medicine on disease targets and pathways.This article aims at providing treatment ideas for the protection of neurons after ischemia.

关 键 词：脑缺血 神经元 自噬 凋亡 中药干预 药理机制 

分 类 号：R285.6[医药卫生—中药学]