HYAL1表达与头颈鳞状细胞癌进展和预后的关系  

The relationship between the expression of HYAL1 and the progression and prognosis of head and neck squamous cell carcinoma

作　　者：苏奎玮 李枭 程刚 SU Kui-wei;LI Xiao;CHENG Gang(Graduate School of Bengbu Medical College,Bengbu,Anhui 233030,China)

机构地区：[1]蚌埠医学院研究生院,安徽蚌埠233030 [2]浙江省人民医院口腔科,浙江杭州310014

出　　处：《中华全科医学》2021年第5期756-759,共4页Chinese Journal of General Practice

基　　金：安徽省教育厅自然科学基金资助项目(KJ2016A480)。

摘　　要：目的本文旨在检查透明质酸酶1(HYAL1)在头颈鳞状细胞癌(HNSCC)中的表达水平及其与头颈鳞状细胞癌(HNSCC)患者的生存关系。方法收集2008-2015年浙江省人民医院行根治性切除的HNSCC患者资料构建组织芯片,通过免疫组织化学检测了258例患者切除的肿瘤标本和附近组织中HYAL1的表达。结果 HYAL1在HNSCC组织中的表达明显低于正常邻近组织(P<0.001)。HYAL1的低表达与肿瘤大小(P=0.011)、淋巴结转移(P=0.025)和TMN分期(P=0.038)显著相关。此外,与高HYAL1表达者相比,低HYAL1表达者与短生存期显著相关(P=0.007)。HYAL1低表达患者的总生存期中位数为36个月,而HYAL1高表达患者的总生存期仍未达到中位数(超过74个月)。在本研究有限的病例中,未发现高表达或低表达HYAL1的患者在年龄、性别、病变部位、HPV感染、吸烟、饮酒、组织学分期有任何差异。结论 HYAL1低表达与HNSCC患者的预后不良有关。HYAL1可能是临床上有价值的预后指标,并且是HNSCC治疗的潜在靶标。Objective This article aims to study the expression level of hyaluronidase 1(HYAL1)in head and neck squamous cell carcinoma(HNSCC)and its relationship with the survival of HNSCC patients.Methods The data of HNSCC patients who underwent radical resection in Zhejiang Provincial People’s Hospital from 2008 to 2015 were collected to construct tissue chips,and the expression of HYAL1 in tumor specimens and nearby tissues from 258 patients was detected by immunohistochemistry.Results The expression of HYAL1 in HNSCC tissues was significantly lower than that of normal adjacent tissues(P<0.001).The low expression of HYAL1 was significantly correlated with tumor size(P=0.011),lymph node metastasis(P=0.025)and TNMs staging system(P=0.038).In addition,compared with high HYAL1 expression,low HYAL1 expression was significantly associated with short survival time(P=0.007).The median overall survival of patients with low HYAL1 expression is 36 months,while the median overall survival of patients with high HYAL1 expression has not yet reached(more than 74 months).It is worth noting that in our limited cases,this study did not find any difference in age,gender,lesion site,HPV infection,smoking,drinking,and histological staging between the patients with high low expression of HYAL1.Conclusion The low expression of HYAL1 is related to the poor prognosis of these HNSCC patients.HYAL1 may be a clinically valuable prognostic indicator and a potential target for HNSCC treatment.

关 键 词：头颈鳞状细胞癌 透明质酸酶1 生物标志物 

分 类 号：R739.91[医药卫生—肿瘤] R730.261[医药卫生—临床医学]