唑来膦酸注射液治疗高龄老年性骨质疏松的药物不良反应分析  

Analysis of Adverse Drug Reactions of Zoledronic Acid Injection in the Treatment of Elderly Osteoporosis

作　　者：樊实真[1] Fan Shizhen(Department of General Medicine,Zhengzhou No.1 People's Hospital,Zhengzhou 450000)

机构地区：[1]郑州市第一人民医院全科医学科,郑州450000

出　　处：《数理医药学杂志》2021年第5期699-701,共3页Journal of Mathematical Medicine

摘　　要：目的:分析唑来膦酸注射液治疗高龄老年性骨质疏松的药物不良反应。方法:选取2018年11月~2019年11月在某院就诊且应用唑来膦酸注射液治疗的82例老年骨质疏松患者为研究对象,根据患者年龄差异将其分为老年组(年龄60~74岁)与高龄组(年龄≥75岁)各41例,比较分析两组的基础资料和药物不良反应发生情况,同时分析药物不良反应与高龄之间的相关性。结果:两组的性别、BMI、骨钙素、骨吸收抑制剂使用率、合并高血压、糖尿病、心脏病率对比,差异无统计学意义(P>0.05);高龄组的药物不良反应发生率明显低于老年组(P<0.05);分析发生与未发生不良反应患者临床资料发现,骨质吸收抑制使用率和年龄是引起药物不良反应的危险因素(P<0.05);通过控制骨质吸收抑制使用率后发现,药物不良反应发生与高龄呈负相关(P<0.05)。结论:与年龄<75岁骨质疏松患者比较,年龄≥75岁患者采用唑来膦酸注射液治疗的药物不良反应发生率明显更低,表明药物不良反应发生率与高龄呈负相关。Objective:To analyze the adverse drug reactions of zoledronic acid injection in the treatment of elderly osteoporosis.Methods:Eighty-two elderly patients with osteoporosis treated with zoledronic acid injection in a hospital from November 2018 to November 2019 were selected as study subjects and divided into elderly group(age 60~74 years old,n=41)and older group(age≥75 years old,n=41)according to the age of the patients.The basic data and adverse drug reactions of the two groups were compared and analyzed,and the correlation between adverse drug reactions and advanced age was also analyzed.Results:There was no significant difference in gender,BMI,osteocalcin,bone resorption inhibitor use rate,combined hypertension,diabetes,and heart disease rate between the two groups(P>0.05).The incidence of adverse drug reactions in the older group was significant lower than the elderly group(P<0.05).Analysis of clinical data of patients with and without adverse reactions showed that the rate of bone resorption inhibition and age were risk factors of adverse drug reactions(P<0.05).By controlling bone repression inhibition use rate,it was found that the occurrence of adverse drug reactions was negatively correlated with advanced age(P<0.05).Conclusion:Compared with osteoporosis patients<75 years of age,the incidence of adverse drug reactions is significantly lower in patients aged≥75 years with zoledronic acid injection,indicating that the incidence of adverse drug reactions is negatively correlated with advanced age.

关 键 词：唑来膦酸注射液 高龄老年性骨质疏松 药物不良反应 

分 类 号：R681.1[医药卫生—骨科学]