氟比洛芬酯联合右美托咪定减少小儿术后躁动及拔管期不良反应的影响  

The Effect of Flurbiprofen Ester Combined with Dexmedetomidine on Postoperative Agitation and Adverse Reactions during Extubation in Children

作　　者：罗春水[1] 薛彦生 严丽梅[1] 杜卫东[1] Luo Chunshui;Xue Yansheng;Yan Limei;Du Weidong(Department of Anesthesiology,Huizhou No.2 Maternal and Child Health Care Hospital,Huizhou 516001;Department of Pediatric Surgery,Huizhou No.2 Maternal and Child Health Care Hospital,Huizhou 516001)

机构地区：[1]惠州市第二妇幼保健院麻醉科,惠州516001 [2]惠州市第二妇幼保健院儿外科,惠州516001

出　　处：《数理医药学杂志》2021年第5期714-716,共3页Journal of Mathematical Medicine

基　　金：惠州市科技计划项目(180513191742739)。

摘　　要：目的:探讨氟比洛芬酯联合右美托咪定减少小儿术后躁动及拔管期不良反应的影响。方法:选取2018年10月~2020年1月某院接受的进行腹腔镜疝气或鞘膜积液手术的患者200例作为研究对象,随机分为A组、B组、C组、D组各50例。A组术中静滴右美托咪定0.5ug/kg;B组术中静滴右美托咪定0.5ug/kg,术毕静脉注射0.7mg/kg氟比洛芬酯;C组术毕静脉注射0.7mg/kg氟比洛芬酯;D组为生理盐水组。治疗后对患者的临床治疗效果进行评估,比较4组患者的麻醉后苏醒时间、拔管时间、在麻醉恢复室内的躁动发生概率以及不同时间血压和心率变化。结果:治疗后A、B组的苏醒时间以及拔管时间稍高于其他两组(P<0.05),A、B组RSS镇静评分高于其他两组(P<0.05),A组与B组苏醒时间、拔管时间及RSS镇静评分相比无明显的统计学意义(P>0.05)。A、B两组患者的躁动发生率均低于C、D组,其中B组患者的躁动发生率最低。麻醉前4组患者收缩压、舒张压以及心率相比无明显统计学意义(P>0.05),拔管后B组患者收缩压、舒张压以及心率均低于其余3组(P<0.05),A、C、D组收缩压、舒张压以及心率相比无明显的统计学意义(P>0.05)。结论:进行腹腔镜疝气或鞘膜积液手术中使用麻醉后,利用氟比洛酚酯联合右美托咪定治疗,虽然会稍延长清醒及拔管时间,但是能够有效减少患儿全麻术后躁动的发生率及有效抑制患儿拔管期的不良反应,维持血流动力学水平以及心率变化,提高临床治疗的有效率。Objective:To investigate the effect of flurbiprofen ester combined with dexmedetomidine on reducing postoperative agitation and adverse reactions during extubation in children.Methods:A total of 200 patients undergoing laparoscopic hernia or hydrocele surgery in a hospital from October 2018 to January 2020 were selected as study subjects and randomly divided into 4 groups,with 50 patients in each group.Group A received dexmedetomidine 0.5ug/kg intraoperatively.Group B received dexmedetomidine intravenous drip 0.5ug/kg during the operation,and flurbiprofen ester 0.7mg/kg after the operation.Group C received 0.7mg/kg flurbiprofen ester intravenously after surgery.Group D was normal saline group.After treatment,the clinical therapeutic effect of the patients was evaluated,and the recovery time,extubation time,the probability of restlessness in the anesthesia recovery room and the changes of blood pressure and heart rate at different times were compared among the four groups.Results:After treatment,the wake time and extubation time of group A and group B were slightly higher than those of the other two groups(P<0.05).RSS sedation scores of group A and group B were higher than those of the other two groups(P<0.05),and there were no statistically significant difference between group A and group B in terms of wake time,extubation time and RSS sedation scores(P>0.05).The incidence of restlessness in group A and group B was lower than that in group C and group D,and group B had the lowest incidence of restlessness.There was no significant difference in systolic blood pressure,diastolic blood pressure and heart rate before anesthesia(P>0.05).The systolic pressure,diastolic blood pressure and heart rate in the group B were lower than those in the other three groups,and there was no statistically significant difference in systolic blood pressure,diastolic blood pressure and heart rate among group A,group C and group D(P<0.05).Conclusion:After anesthesia in laparoscopic hernia or hydrocele surgery,the application of flurbipro

关 键 词：氟比洛芬酯 右美托咪定 腹腔镜疝气手术 鞘膜积液手术 

分 类 号：R614.2[医药卫生—麻醉学]