氢吗啡酮复合罗哌卡因用于髋关节置换术后PCEA的镇痛效果  

Analgesic Effect of Hydromorphone Combined with Ropivacaine for PCEA after Hip Replacement

作　　者：莫肖莲 Mo Xiaolian(Department of Anesthesiology,Guangning Hospital of Traditional Chinese Medicine,Zhaoqing 526300)

机构地区：[1]广宁县中医院麻醉科,肇庆526300

出　　处：《数理医药学杂志》2021年第5期717-719,共3页Journal of Mathematical Medicine

摘　　要：目的:探讨氢吗啡酮复合罗哌卡因用于髋关节置换术后自控硬膜外镇痛(PCEA)的镇痛效果。方法:选取2018年1月~2020年1月于某院行髋关节置换术后采用PCEA镇痛的患者共52例,采取随机数表法分为A组和B组各26例,A组PCEA方案为氢吗啡酮复合罗哌卡因,B组PCEA方案为盐酸吗啡复合罗哌卡因,比较两组镇痛、镇静效果,血清白介素-6、C反应蛋白水平以及不良反应发生情况。结果:A组患者术后4h、8h、12h及24h的静息VAS疼痛评分及活动VAS疼痛评分均低于B组(P<0.05);A组术后4h、8h及12h的Ramsay评分均低于B组(P<0.05);两组术后较术前IL-6、CRP水平均升高(P<0.05),但B组显著高于A组(P<0.05);A组不良反应发生率低于B组(P<0.05)。结论:氢吗啡酮复合罗哌卡因用于髋关节置换术后PCEA镇痛,镇静效果显著,可减轻术后炎症反应,且不良反应少。Objective:To investigate the analgesic effect of hydromorphone combined with ropivacaine in patient-controlled epidural analgesia(PCEA)after hip replacement.Methods:A total of 52 patients with PCEA analgesia after hip replacement in a hospital from January 2018 to January 2020 were selected and randomly divided into group A and group B,with 26 cases in each group.The analgesic and sedative effects,serum interleukin-6,C-reactive protein levels and adverse reactions were compared between the two groups.Results:The resting VAS pain scores and active VAS pain scores at 4h,8h,12h and 24h after operation in the group A were lower than those in the group B(P<0.05);Ramsay scores of group A at 4h,8h and 12h were lower than those of group B(P<0.05);The levels of IL-6 and CRP in two groups were higher than those before operation,and the group B was significantly higher than group A(P<0.05).The incidence of adverse reactions in group A was lower than that in group B(P<0.05).Conclusion:Hydromorphone combined with ropivacaine has significant analgesic and sedative effects on PCEA after hip arthroplasty,and can reduce postoperative inflammatory reaction with less adverse reactions.

关 键 词：氢吗啡酮 盐酸吗啡 髋关节置换术 自控硬膜外镇痛 

分 类 号：R687.4[医药卫生—骨科学]