H型高血压患者血尿酸水平与轻度认知功能障碍的相关性分析  

Serum Uric Acid Level and Mild Cognitive Impairment in Patients with H-type Hypertension

作　　者：李倩 赵建华[1] 彭雪 孟利芳 刘昊 王瑾 刘俊丽 赵盼盼[1] 王凡 李少敏 LI Qian;ZHAO Jianhua;PENG Xue;MENG Lifang;LIU Hao;WANG Jin;LIU Junli;ZHAO Panpan;WANG Fan;LI Shaomin(Department of Neurology,First Affiliated Hospital of Xinxiang Medical University/Henan Key Laboratory of Neurorestoratology/Henan Joint International Research Laboratory of Neurorestoratology for Senile Dementia,Xinxiang 453100,China;Ann Romney Center for Neurologic Diseases,Brigham and Women's Hospital,Harvard Medical School,Boston 02115,United States)

机构地区：[1]新乡医学院第一附属医院神经内科,河南省神经修复重点实验室,河南省老年性痴呆神经修复国际联合实验室,河南省新乡市453100 [2]美国哈佛大学医学院布莱根妇女医院神经疾病研究中心,波士顿02115

出　　处：《中国全科医学》2021年第20期2527-2531,共5页Chinese General Practice

基　　金：河南省自然科学基金资助项目(182300410389);河南省医学科技攻关计划联合共建项目(LHGJ20190436);河南省高等学校重点科研项目(16B20019)。

摘　　要：背景我国H型高血压患者的发病率逐年增高,易导致认知功能减退,血尿酸(SUA)在H型高血压患者中水平升高,且与轻度认知功能障碍(MCI)可能存在一定关联。目的探讨H型高血压患者SUA水平与MCI的相关性,以期为H型高血压所致认知功能减退寻找早期识别指标。方法选取2019年1月—2020年9月于新乡医学院第一附属医院就诊的H型高血压患者89例,收集患者临床资料,包括性别、年龄、教育年限、身高、体质量、体质指数(BMI)、吸烟史、饮酒史、冠心病史、高脂血症史、糖尿病史、收缩压(SBP)、舒张压(DBP)、同型半胱氨酸(Hcy)、SUA。选用简易精神状态量表(MMSE)、中文版蒙特利尔认知评估量表(MoCA)进行认知功能评估。依据认知功能评估结果将患者分为H型高血压合并MCI组(A组,n=47),H型高血压认知功能正常组(B组,n=42),选取同期健康体检者40例为对照组(C组)。H型高血压合并MCI影响因素分析采用多因素Logistic回归分析,H型高血压患者SUA水平与MoCA评分的相关性采用Pearson相关分析。结果A组身高低于C组(P<0.05);A、B组SBP、DBP、Hcy高于C组(P<0.05);B组SUA水平高于A、C组(P<0.05)。多因素Logistic回归分析结果显示,SUA水平升高为H型高血压合并MCI的保护因素,SBP升高为H型高血压合并MCI的危险因素(P<0.05)。H型高血压患者的SUA水平与MoCA评分呈正相关(r=0.279,P=0.008)。结论H型高血压患者SUA水平与MCI的发生相关,可能是H型高血压合并MCI的保护性因素。Background H-type hypertension easily brings about the decline of cognitive,whose incidence in China is increasing with years.Elevated serum uric acid(SUA)levels in patients with H-type hypertension may be related to mild cognitive impairment(MCI).Objective The present study aimed at investigating the correlation between SUA level and MCI in patients with H-type hypertension to find early identification indicators of cognitive decline caused by H-type hypertension.Methods Eighty-nine patients with H-type hypertension and 40 health examinees were selected from the First Affiliated Hospital of Xinxiang Medical University from January 2019 to September 2020.Clinical data of the participants were collected,including gender,age,years of education,height,weight,and body mass index,history of smoking,drinking,coronary heart disease,hyperlipidemia,and diabetes,systolic blood pressure(SBP),diastolic blood pressure(DBP),homocysteine(Hcy),SUA.The Mini-Mental State Examination(MMSE)and the Chinese version of the Montreal Cognitive Assessment(MoCA)were used to assess cognitive function in hypertension patients,and by the assessment results,the patients were divided into H-type hypertension with MCI subgroup(n=47),and H-type hypertension with normal cognitive function subgroup(n=42).Multivariate Logistic regression analysis was carried out to identify the factors associated with H-type hypertension with MCI.The correlation between SUA level and MoCA score in H-type hypertension patients was analyzed by Pearson correlation analysis.Results Compared to health examinees,H-type hypertension patients with MCI had lower mean height,and higher mean levels of SBP,DBP and Hcy(P<0.05),those with normal cognitive function had higher mean levels of SBP,DBP,Hcy and SUA(P<0.05).In addition,H-type hypertension patients with normal cognitive function had higher mean SUA level than those with MCI(P<0.05).Multivariate Logistic regression analysis found that elevated SUA was associated with decreased risk of MCI,while elevated SBP was associated

关 键 词：高血压 尿酸 H型高血压 认知功能障碍 半胱氨酸 相关性分析 

分 类 号：R544.1[医药卫生—心血管疾病]