低浓度含铅细颗粒物暴露大鼠体内生物转运研究  

The Biological Transport of Low Concentrations Pb-containing Fine Particulate Matter in Rats

作　　者：夏栋林[1,2] 仇昀 王乡儿 陈超 张小鑫[1] 袁善美 顾海鹰 胡勇[2] XIA Donglin;QIU Yun;WANG Xianger;CHEN Chao;ZHANG Xiaoxin;YUAN Shanmei;GU Haiying;HU Yong(School of Public Health,Nantong University,Nantong,Jiangsu 226019,China;College of Engineering and Applied Sciences,Nanjing University,Nanjing,Jiangsu 210093,China;Nantong Vocational University,Nantong,Jiangsu 226019,China)

机构地区：[1]南通大学公共卫生学院,江苏南通226019 [2]南京大学现代工程与应用科学学院,南京210023 [3]南通职业大学,江苏南通226019

出　　处：《中国无机分析化学》2021年第3期12-17,共6页Chinese Journal of Inorganic Analytical Chemistry

基　　金：国家重点研究与开发计划(2018YFF0215500);南通市科技项目(JC2019139,JC2019050);江苏省高校自然科学研究面上项目(19KJB430032)。

摘　　要：食品接触性塑料制品、可再生资源、汽车尾气中含有低浓度铅。铅等重金属体内蓄积严重影响机体健康,但机体长期暴露于铅环境的代谢依然未知。以低剂量含铅细颗粒物暴露为场景,探讨其在大鼠体内的生物转运及体内分布。通过比较每日吸入染毒(7.05±0.83)μg/m3及经口染毒0.42μg/d,连续染毒28 d。结果显示含铅细颗粒物入血的速度比经口途径快,在肺内蓄积浓度达(4.2±0.67)μg/g,与经口染毒组比较有显著统计学差异(P<0.01);排泄方面,吸入含铅细颗粒物以粪便、尿液形式排出为主,与经口染毒组比较具有体内蓄积量大、排泄慢、在股骨和肋骨内蓄积量大的特点。因此,吸入含铅细颗粒物暴露体内蓄积量大,代谢速度慢,暴露危害比经口途径更大。Accumulation of fine particulate matter,such as lead,food contact plastic products or automobile exhaust,is one of the most important risk factors for human health.The Pb-containing fine particulate matter was chosen to study the biological transport and biodistribution after inhalation exposure in rats.After exposure,blood,urine,feces,important organs,and bones were collected regularly,of which Pb levels were tested by atomic absorption meter.Pb-containing fine particles,with(7.05±0.83)μg/m3,entered the blood faster after inhalation exposure and accumulated in lung at a higher concentration(4.2±0.67)μg/g,and which was significant difference compared with the oral administration group(P<0.01).Pb-containing fine particles were excreted mainly through urine at low excretion rate,and most of them were accumulated in rib and femur.We can draw that Pb-containing fine particulate matter increased lung exposure and accumulation in bone after inhalation exposure.

关 键 词：含铅细颗粒物 吸入染毒 代谢 蓄积 

分 类 号：O657.31[理学—分析化学] TH744.11[理学—化学]