综合型有机化学实验设计:N-苄氧基-2-氯-2-苯乙酰胺的合成与表征  

Design of Comprehensive Organic Experiment:Synthesis and Characterization of N-(Benzyloxy)-2-Chloro-2-Phenylacetamide

作　　者：王刚 孙琦 何照林 奚江波 袁华 尹传奇[1,2] WANG Gang;SUN Qi;HE Zhao-Lin;XI Jiang-Bo;YUAN Hua;YIN Chuan-Qi(School of Chemistry and P3nvironmental Enginctiring.Wuhan Instilute of Technology,Wuhan 130205.China;National Demonslration Center for Environmcnial and Chemical Engineering Clean Production Experimental Education,Wuhan Institute of Technology,Wuhan 430205,China)

机构地区：[1]武汉工程大学化学与环境工程学院,湖北武汉430205 [2]武汉工程大学环境与化工清洁生产国家级实验教学示范中心,湖北武汉430205

出　　处：《化学教育（中英文）》2021年第8期49-52,共4页Chinese Journal of Chemical Education

基　　金：湖北省教学研究项目(2017327);武汉工程大学教学研究项目(X2018042)。

摘　　要：以苯甲醛和丙二腈为起始原料,经Knoevnagel缩合、环氧化、环氧化合物开环等3步反应,合成N-苄氧基-2-氯-2-苯乙酰胺,并对产物进行红外和核磁表征。实验内容与基础有机化学理论知识高度契合。结合产物分子结构的波谱分析,对于培养学生有机化合物多步合成能力和波谱解析能力,具有很好的教学效果。Using benzaldehyde and malononitrile as starting materials,N-(benzyloxy)-2-chloro-2-phenylacetamide was successfully obtained through a three-steps procedure including Knoevnagel condensation,epoxidation and epoxide ring opening reactions,and the product was characterized by IR and NMR.As a comprehensive organic experiment,the experimental content is quite closely related to the theoretical knowledge points.In combination with the IR and NMR spectroscopy analysis,this experiment improved students’capability of multi-step organic synthesis and spectroscopy analysis.And a good teaching effect could be achieved by the experiment.

关 键 词：N-苄氧基-2-氯-2-苯乙酰胺 合成与表征 综合型有机化学实验 

分 类 号：O625.63-4[理学—有机化学] G642.423[理学—化学]