1,25-(OH)_(2)D_(3)对气道炎症及气道重塑的影响  

Research progress of 1,25-(OH)D in airway inflammation and airway remodeling

作　　者：杨胜红 姚培学 欧应勇 欧阳瑶 YANG Shenghong;YAO Peixue;OU Yingyong;OUYANG Yao(Department of PCCM and Critical Care Medicine Respiratory,Affiliated Hospital of Zunyi Medical University,Zunyi 563000,China)

机构地区：[1]遵义医科大学附属医院PCCM呼吸一病区,贵州遵义563000

出　　处：《实用医学杂志》2021年第8期1080-1083,共4页The Journal of Practical Medicine

基　　金：国家自然科学基金项目(编号:82060005);贵州省科技计划项目(编号:黔科合支撑[2020]4Y141号)。

摘　　要：1,25-(OH)2D3是Vit D的活性形式,因具有抗炎和抗纤维化作用而在气道炎症和气道重塑中扮演重要角色。1,25-(OH)2D3通过减少炎性因子、诱导抗菌肽的释放、结合免疫细胞Vit D受体在气道中发挥抗炎作用。同时1,25-(OH)2D3减轻气道上皮纤维化、影响气道细胞如气道平滑肌细胞、气道上皮细胞、气道成纤维细胞的增殖及分泌。此外1,25-(OH)2D3减少TGF-β1、IL-17A的表达。本文就1,25-(OH)2D3在气道炎症及气道重塑中的研究展开综述。1,25-(OH)2D3,the active form of Vit D,plays an important role in airway inflammation and remodeling.due to its anti-inflammatory and antifibrosis effects.1,25-(OH)2D3 plays an anti-inflammatory role in airway by reducing inflammatory factors,inducing the release of antimicrobial peptides and binding to Vit D receptor.At the same time 1,25-(OH)2D3 can reduce airway epithelial fibrosis and affect the proliferation and secretion of airway cells such as airway smooth muscle cells,airway epithelial cells and airway fibroblasts. In addition,1,25-(OH)2D3 decreased the expression of TGF-β1 and IL-17 A. This article reviews the research of 1,25-(OH)2D3 in airway inflammation and airway remodeling.

关 键 词：1 25-(OH)2D3 气道炎症 气道重塑 

分 类 号：R562.1[医药卫生—呼吸系统]