针刺结合麦粒灸治疗大学生抑郁症的临床观察及对血清5-羟色胺的影响  

Clinical observation of acupuncture combined with moxibustion on college students with depression

作　　者：蔡慧倩 粟胜勇[2] 代琪 蒋香玉 张熙 黄梅 林安 CAI Hui-qian;SU Sheng-yong;DAI Qi;JIANG Xiang-yu;ZHANG Xi;HUANG Mei;LIN An(The First Clinical Medical College,Guangxi University of Chinese Medicine,Nanning 530023,China;Department of Acupuncture and Moxi­bustion,The First Affiliated Hospital of Guangxi University of Chinese Medicine,Nanning 530023)

机构地区：[1]广西中医药大学第一临床医学院,南宁530023 [2]广西中医药大学第一附属医院针灸科,南宁530023

出　　处：《针刺研究》2021年第4期330-334,共5页Acupuncture Research

基　　金：十二五科技支撑计划分课题(No.2012BAI24B01);国家自然科学基金项目(No.81960895);广西壮族自治区自然科学基金项目(No.2018GXNSFAA281111)。

摘　　要：目的:观察针刺结合麦粒灸治疗大学生抑郁症的临床疗效,探讨其对血清5-羟色胺(5-HT)的影响。方法:将60例大学生抑郁症患者按照随机数字表法分成西药组27例和针灸组28例。针灸组选用少阳经穴为主针刺结合麦粒灸治疗,每周治疗3次,隔日1次,西药组每日口服盐酸氟西汀胶囊20 mg,两组均连续治疗8周。比较两组治疗前及治疗2、4、8周后汉密尔顿抑郁量表(HAMD-17)、抑郁自评量表(SDS)评分的变化,治疗后检测血清5-HT含量并记录不良反应。结果:与治疗前比较,针灸组治疗2周后HAMD-17、SDS评分较治疗前开始下降(P<0.05);西药组在治疗4周后HAMD-17、SDS评分开始下降(P<0.05)。治疗2、4、8周后,针灸组HAMD-17、SDS评分均较西药组下降更明显(P<0.05)。治疗8周后,两组血清5-HT含量均较治疗前显著提高(P<0.05),针灸组血清5-HT含量与西药组比较差异无统计学意义(P>0.05)。针灸组不良反应评分低于西药组(P<0.05)。针灸组总有效率为92.86%(26/28),优于西药组的81.48%(22/27,P<0.05)。结论:针刺结合麦粒灸治疗大学生抑郁症疗效优于口服盐酸氟西汀胶囊,且针刺结合麦粒灸治疗大学生抑郁症起效快,不良反应少。Objective To observe the clinical efficacy of acupuncture combined with moxibustion with seed-sized moxa cone in the treatment of depression in college students, and explore its effect on serum 5-hydroxytryptamine(5-HT). Methods Sixty undergraduates with depression were divided into acupuncture-moxibustion group and medication group according to the random number table, with 30 patients in each group. The patients in acupuncture-moxibustion group received acupuncture and moxibustion with seed-sized moxa cone at acupoints on Shaoyang meridian according to the method of "rotating the pivot and regulating the qi", one time every other day. The patients in medication group received oral administration of fluoxetine hydrochloride capsule 20 mg once a day, and both groups were treated continuously for 8 weeks. The scores of Hamilton depression(HAMD-17) scale, self-rating depression scale(SDS) and serum 5-HT content before and after treatment were compared between the two groups.Results Compared with before treatment, the HAMD-17 and SDS scores of the acupuncture-moxibustion group began to decrease after 2 weeks of treatment(P<0.05);while the HAMD-17 and SDS scores of the the medication group began to decrease after 4 weeks of treatment(P<0.05). After 2, 4 and 8 weeks of treatment, the HAMD-17 and SDS scores of the acupuncture-moxibustion group decreased more significantly than the medication group(P<0.05). The 5-HT contents of the two groups were significantly higher than those before treatment(P<0.05),and there was no significant difference in serum 5-HT content between the two groups(P>0.05). The adverse reaction score of the acupuncture-moxibustion group was lower than that of the medication group(P<0.05). The total effective rate of the acupuncture-moxibustion group was 92.86%(26/28), better than the medication group 81.48%(22/27,P<0.05). Conclusion Acupuncture combined with seed-sized moxa cone moxibustion is more effective than oral administration of fluoxetine hydrochloride in treating college students’ depres

关 键 词：抑郁症 针灸 汉密尔顿抑郁量表 抑郁自评量表 5-羟色胺 

分 类 号：R246[医药卫生—针灸推拿学]