磁共振延迟强化技术与HCM患者血浆NT-proBNP、Hcy变化的关系  

The Relationship between the Parameters of MRI-LGE and the Changes of Plasma NT-proBNP and Hcy in Patients with Hypertrophic Cardiomyopathy

作　　者：刘铁芳[1] 胡坚兴 张晓晶[1] LIU Tiefang;HU Jianxing;ZHANG Xiaojing(The First Medical Center of PLA General Hospital,Beijing 100853,P.R.China)

机构地区：[1]解放军总医院第一医学中心,北京100853

出　　处：《影像科学与光化学》2021年第3期391-395,共5页Imaging Science and Photochemistry

摘　　要：本文探讨了磁共振延迟强化(MRI-LGE)与肥厚型心肌病(HCM)患者血浆氨基末端脑钠肽前体(NT-proBNP)、同型半胱氨酸(Hcy)水平变化的关系。选取HCM患者76例作为研究对象,所有患者均接受心脏MRI检查,根据LGE结果分为LGE阳性组和LGE阴性组,对比两组的总LGE率、LGE体积、LGE质量、NT-proBNP、Hcy水平,并分析NT-proBNP、Hcy水平与LGE参数的相关性。结果显示,LGE阳性组患者的总LGE率、LGE体积、LGE质量均显著高于LGE阴性患者(P<0.05);LGE阳性组患者的NT-proBNP、Hcy测定值高于LGE阴性患者(P<0.05);LGE阳性HCM患者NT-proBNP、Hcy测定值与总LGE率、LGE体积、LGE质量均呈显著的正相关关系(P<0.05)。HCM伴有心肌纤维化患者的NT-proBNP、Hcy明显升高,且与纤维化程度有关。In this study,the relationship between the parameters of late gadolinium enhancement(LGE)and the changes of plasma N-terminal pro-brain natriuretic peptide(NT-proBNP)and homocysteine(Hcy)in patients with hypertrophic cardiomyopathy(HCM)was investigated.Seventy-six HCM patients were selected as research objects.All patients underwent cardiac MRI examination,they were divided into LGE-positive group and LGE-negative group according to the LGE results.The total LGE rate,LGE volume,LGE quality,NT-proBNP,Hcy levels of the two groups were compared,and the correlation between NT-proBNP,Hcy levels and LGE parameters was analyzed.The results showed that the total LGE rate,LGE volume,and LGE quality of the LGE-positive group were significantly higher than those of the LGE-negative group(P<0.05).The measured values of NT-proBNP and Hcy of LGE-positive patients were higher than those of LGE-negative patients(P<0.05).The measured values of NT-proBNP and Hcy in LGE-positive HCM patients were significantly positively correlated with the total LGE rate,LGE volume,and LGE quality(P<0.05).NT-proBNP and Hcy in HCM patients with myocardial fibrosis are significantly increased,and are related to the degree of fibrosis.

关 键 词：磁共振延迟强化 延迟钆增强 肥厚型心肌病 氨基末端脑钠肽前体 同型半胱氨酸 

分 类 号：R542.2[医药卫生—心血管疾病]