MtDNA mutations and aging--not a closed case after all?  

作　　者：Alexander M.Wolf 

机构地区：[1]Laboratory for Morphological and Biomolecular Imaging,Faculty of Medicine,Nippon Medical School,Tokyo,Japan

出　　处：《Signal Transduction and Targeted Therapy》2021年第3期555-556,共2页信号转导与靶向治疗（英文）

摘　　要：In a recent paper in Nature Cancer,Smith et al.demonstrate that mitochondrial DNA(mtDNA)mutations can confer a growth advantage to intestinal tumors by remodeling cell metabolism,particularly toward elevated de novo serine synthesis.1 For the reasons outlined below,in the past decade,the field of mtDNA biology has experienced a relative loss of relevance.The findings of Smith et al.breathe welcome new life into the complex field of mtDNA contributions to aging and cancer.

关 键 词：al. METABOLISM ELEVATED 

分 类 号：R339.38[医药卫生—人体生理学]