化学交换饱和转移效应量化方法的应用进展  

The quantification methods of the confounding effects in chemical exchange saturation transfer

作　　者：窦晗 郑阳[1] 王晓明[1] DOU Han;ZHENG Yang;WANG Xiaoming(Department of Radiology,Shengjing Hospital of China Medical University,Shenyang 110000,China)

机构地区：[1]中国医科大学附属盛京医院放射科,沈阳110000

出　　处：《磁共振成像》2021年第5期118-120,124,共4页Chinese Journal of Magnetic Resonance Imaging

基　　金：国家自然科学基金(编号:81871408、81271631);国家自然科学基金青年基金(编号:81801658);盛京医院自由研究者基金(编号:201402)。

摘　　要：化学交换饱和转移(chemical exchange saturation transfer,CEST)是一种新兴的分子成像技术,通过分子间化学交换现象间接获得代谢物浓度信息,进行疾病诊断、预后评估等。然而得到的CEST信号并不是单纯来自化学交换,而混杂了诸如传统磁化转移效应(magnetization transfer,MT)、直接饱和效应(direct water saturation,DS)、核奥氏效应(nuclear overhauser enhancement,NOE)等效应。去除或利用这些效应以提高量化的准确度和成像质量是向临床转化的关键。Chemical exchange saturation transfer(CEST)is a new molecular imaging technique,which can be used to obtain metabolite concentration information indirectly for clinical diagnosis and prognosis evaluation.However,the CEST signal obtained is not simply from chemical exchange,but contains mixed effects such as direct water saturation(DS),traditional magnetization transfer(MT),nuclear overhauser enhancement(NOE)and so on.How to remove or utilize these effects to improve the quantization accuracy and imaging quality is crucial to clinical transformation.

关 键 词：化学交换饱和转移 磁化传递 磁共振成像 核奥氏效应 直接饱和 

分 类 号：R445.2[医药卫生—影像医学与核医学]