肿瘤微环境响应型^(19)F-MR分子成像纳米探针  

Tumor microenvironment responsive ^(19)F-MR molecular imaging nanoprobe

作　　者：胡雪松 卫佳楠 王洪斌 吴丽娜[1,2] 王凯[1,2] 孙夕林[1,2] HU Xuesong;WEI Jianan;WANG Hongbin;WU Lina;WANG Kai;SUN Xilin(TOF-PET/CT/MR Center,Harbin Medical University,Harbin 150028,China;Molecular Imaging Research Center(MIRC),Harbin Medical University,Harbin 150028,China)

机构地区：[1]哈尔滨医科大学附属第四医院TOF-PET/CT/MR中心,哈尔滨150028 [2]哈尔滨医科大学分子影像研究中心,哈尔滨150028

出　　处：《磁共振成像》2021年第5期121-124,共4页Chinese Journal of Magnetic Resonance Imaging

基　　金：国家自然科学基金(编号:81627901);国家重点基础研究发展计划基金(编号:2015CB931800);黑龙江省自然科学基金(编号:JQ2020H002)。

摘　　要：肿瘤微环境(tumor microenvironment,TME)与肿瘤的发生、转移及其所在组织的结构、功能密切相关。在体研究肿瘤细胞与TME之间的相互作用机制,是基础和临床研究癌症发生发展、研发肿瘤精准诊断新技术以及开发有效抑制肿瘤新策略的迫切需求。分子影像学(molecular imaging)着眼于生物过程的分子水平变化,对早期TME中分子改变及环境变化的研究具有重要意义。现已研制出多种针对TME响应的19F-MR纳米分子成像探针,这类探针可在复杂TME中的某些特定刺激下,使含氟小分子核团暴露,19F-MR信号明显增强。利用探针这一环境响应特性,结合19F-MR成像,可在分子水平早期可视化TME中的恶性生物学行为,为实现肿瘤早期诊断及精准治疗提供有利支持。该综述从基础及临床研究需求出发,对已研发的TME响应型纳米分子成像探针展开评述,以期为新型纳米探针的设计、制备及临床转化提供研究思路及理论依据。Tumor microenvironment(TME)is closely related to the occurrence and metastasis of tumors and the structure and function of the tumor tissues.In vivo research on the interaction mechanism between tumor cells and TME is an urgent need for basical and clinical research on the occurrence and development of cancer,the development of new technology for accurate tumor diagnosis,and the development of new strategy for effective tumor inhibition.Molecular imaging focuses on molecular changes in biological processes,and early intervention and improvement of prognosis are of great significance for the study of molecular changes and environmental changes in early TME.With the continuous development of nanotechnology,a variety of 19F-MR nanomolecular imaging probes have been developed in response to TME.Such probes can change their molecular conformations under certain stimuli in complex TME,exposing the 19F nuclear mass and significantly enhancing the 19F-MR signal.By utilizing the environmental response characteristic of probe and combining with 19F-MR imaging,abnormal malignant biological behaviors in TME can be visualized at the early molecular level,providing favorable support for the realization of early diagnosis of tumor and guidance of precise treatment of tumor.This review based on basic and clinical studies,reviews the developed TME responsive nanomolecular imaging probes,so as to provide research ideas and theoretical basis for the design,preparation and clinical transformation of the new 19F-MR nanomolecular imaging probes.

关 键 词：肿瘤微环境 分子影像学 纳米分子成像探针 ^(19)氟 磁共振成像 智能环境响应 

分 类 号：R445.2[医药卫生—影像医学与核医学] R730.5[医药卫生—诊断学]