Fluorescence enhancement and cytotoxicity reduction of bis-viologen biphenyl by complexation of cucurbit[7]uril  

作　　者：Jing Zhou Shengzhen Hou Jin Zhang Yanru Chen Hao Chen Yebang Tan 

机构地区：[1]School of Chemistry and Chemical Engineering,Shandong University,Ji'nan 250100,China [2]Key Laboratory of Special Functional Aggregated Materials,Ministry of Education,Shandong University,Ji'nan 250100,China

出　　处：《Chinese Chemical Letters》2021年第2期725-728,共4页中国化学快报（英文版）

基　　金：supported by the National Natural Science Foundation of China (No.21374055);the Fundamental Research Funds of Shandong University (No.11190078614092)。

摘　　要：The effect of cucurbit[7]uril(CB[7]) on fluorescence properties and biocompatibility of the bis-viologen biphenyl molecule(BPV22+) was investigated by using 1 H NMR spectroscopy,fluorescence emission titration,and in vitro cytotoxicity experiments.CB[7] can be combined with BPV22+ in a stoichiometric ratio of 1:1 and 2:1.After the formation of host-guest complex,the fluorescence emission intensity of BPV22+ increased significantly,and the emission spectrum blue shifted.Meanwhile,the host-guest complexes showed better biocompatibility than BPV22+ in cell cytotoxicity studies.Results of this paper lay a foundation for the development of host-guest type of fluo rescent probes,biological imaging and so forth.

关 键 词：uril Host-guest complex Fluorescence enhancement Improvement of biocompatibility 

分 类 号：Q503[生物学—生物化学] O657.3[理学—分析化学]