Phenoxazine-based supramolecular tetrahedron as biomimetic lectin for glucosamine recognition  

作　　者：Yuchao Li Xuezhao Li Lili Li Bing Xiao Jinguo Wu Hechuan Li Danyang Li Cheng He 

机构地区：[1]State Key Laboratory of Fine Chemicals,Dalian University of Technology,Dalian 116024,China

出　　处：《Chinese Chemical Letters》2021年第2期735-739,共5页中国化学快报（英文版）

基　　金：the National Natural Science Foundation of China (Nos.21701019 and 21861132004);Doctoral Scientific Research Launching Fund Project of Liaoning province (No.2019BS-050)。

摘　　要：The design and synthesis of a phenoxazine-based metal-organic tetrahedro n(Zn4L4) as biomimetic lectin for selectively recognition of glucosamine(GlcN) was reported.Different from the free phenoxazinebased ligand(L),Zn4L4 displayed the highest fluorescent intensity enhancement efficiency toward GlcN over other related natural mono-and disaccharides.Fluorescence titration demonstrated a 1:1 stoichiometric host-guest complex was formed with an association constant about 4.03 × 104 L/mol.1H NMR spectroscopic studies confirmed this selectivity resulted from the multiple hydrogen bonding interactions formed between GlcN and Zn4L4.The present results suggested that rational arrangement of recognition sites in the confined space of metal-organic cage is crucial for the selectivity toward target guests.

关 键 词：GLUCOSAMINE PHENOXAZINE Metal-organic cage Fluorescence Host-guest complex 

分 类 号：O657.3[理学—分析化学]