银屑病角质形成细胞增殖机制的研究进展  

Research progress on the proliferation mechanism of keratinocytes in psoriasis

作　　者：孙冷冰 龚坚 刘巧 SUN Leng-bing;GONG Jian;LIU Qiao(Jiangxi University of Traditional Chinese Medicine,Nanchang 330004,China;the Fifth People's Hospital of Hainan Province;the Second Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine)

机构地区：[1]江西中医药大学,330004 [2]海南省第五人民医院 [3]江西中医药大学第二附属医院

出　　处：《天津医药》2021年第5期545-549,共5页Tianjin Medical Journal

基　　金：国家自然科学基金资助项目(81860848);国家重点研发计划“中医药现代化研究”重点专项(2018YFC1705300);江西中医药大学一流学科建设科研启动基金项目(JXSYLXK-ZHYI011,JXSYLXK-ZHYI046)。

摘　　要：银屑病的发病机制极其复杂,角质形成细胞(KCs)异常增殖是其重要的病理特征之一。在致病过程中,诸多因素可引起KCs增殖,且各因素间相互影响致使银屑病反复发作,难以治愈。本文从炎性细胞因子、氧化应激、微小RNA以及中医药拮抗KCs增殖等方面进行综述,为深入研究银屑病的发病机制及临床精准治疗提供参考。Psoriasis is a common chronic inflammatory skin disease.Its pathogenesis is extremely complex.The abnormal proliferation of keratinocytes(KCs)is one of its important pathological features.In the process of pathopoiesis,many factors can cause proliferation of KCs,and the interaction of various factors leads to the recurrence of psoriasis,which is more difficult to cure.In this paper,we focus on inflammatory cytokines,oxidative stress,microRNA and traditional Chinese medicine antagonizing the proliferation of KCs,so as to provide reference for further study of pathogenesis and clinical precise treatment of psoriasis.

关 键 词：银屑病 细胞增殖 中医疗法 细胞因子类 微RNAS 角质形成细胞 

分 类 号：R758.63[医药卫生—皮肤病学与性病学]