地西泮致排尿功能障碍2例并文献复习  

Two cases of Dysuria Caused by Diazepam and Literature Review

作　　者：支晓慧 王晓刚 周涛[3] 邵琬迪 杨洛宁 刘化学[3] ZHI Xiaohui;WANG Xiaogang;ZHOU Tao;SHAO Wandi;YANG Luoning;LIU Huaxue(Department of Pharmacy,Linyi Mental Health Center,Linyi 276005,China;Affiliated Hospital of Shandong Medical College,276004;Integrated department Department of Pharmacy,Linyi Mental Health Center,Linyi 276005)

机构地区：[1]山东省临沂市精神卫生中心药学部,276005 [2]山东医学高等专科学校附属医院,276004 [3]山东省临沂市精神卫生中心综合科,276005

出　　处：《中国药物滥用防治杂志》2021年第2期228-233,共6页Chinese Journal of Drug Abuse Prevention and Treatment

摘　　要：目的:探讨地西泮致排尿功能障碍的临床特点。方法:报道我院收治的2例地西泮致排尿功能障碍患者的诊治过程,并对这2例以及通过检索收集到的文献病例的主要临床资料进行汇总分析讨论。结果:纳入汇总分析的共5例病例,男性3例,女性2例;年龄37~70岁;治疗焦虑失眠的2例,成瘾者1例,酒精性精神障碍1例,自杀1例;其中单用地西泮2例,合并用药3例;5例患者发生排尿功能障碍的时间为用药的4.5小时~4年,个体差异大。发生排尿障碍后,5例均停用地西泮,其中酒精障碍、成瘾者及合并前列腺增生患者发生尿潴留后均予导尿管导尿对症处理,酒精障碍者还采用了中医理疗缓解尿潴留症状,上述3例患者均在彻底停药之后,尿潴留症状消失,可自行排尿;其他2例在停用地西泮后的1~3天排尿障碍消失。结论:地西泮可引起排尿功能障碍,值得临床关注,特别有合并前列腺增生的老年患者更易发生。Objective:to investigate the clinical characteristics of diazepam induced voiding dysfunction.Methods:to report the diagnosis and treatment process of 2 patients with urinary dysfunction caused by diazepam in our hospital,and to summarize,analyze and discuss the main clinical data of these 2 cases and the literature cases collected by searching.Results:a total of 5 cases were included in the summary analysis,including 3 males and 2 females,aged 37-70 years;2 cases of anxiety and insomnia,1 case of addiction,1 case of alcoholic mental disorder and 1 case of suicide;among them,2 cases were treated with diazepam alone and 3 cases were treated with combined medication;the time of urination dysfunction of 5 patients was 4.5 hours-4 years of medication,with great individual difference.Diazepam was stopped in all 5 patients after urination disorders.All patients with alcohol disorders,addicts and patients with benign prostatic hyperplasia were treated with catheter catheterization.The patients with alcohol disorders also treated with TCM physical therapy to relieve symptoms.All 3 patients had disappeared after urination,and their urine retention was self urinating.The other 2 cases were relieved after 1-3 days of stopping diazepam.The patient had dysuria.Conclusion:diazepam can cause voiding dysfunction,which is worthy of clinical attention,especially in elderly patients with benign prostatic hyperplasia.

关 键 词：地西泮 排尿功能障碍 排尿困难 尿潴留 药师 失眠焦虑 酒精障碍 

分 类 号：R969[医药卫生—药理学]