不同分型银屑病患者的药物使用现状及重金属中毒情况调查研究  

Psoriasis Drug Abuse and Reasonable Treatment

作　　者：张晓辉 王朋军[2] ZHANG Xiaohui;WANG Pengjun(Department of Dermatology,Jiahe Central Township Health Center,Taiqian County,Puyang,Henan Province,457600 China;Department of Dermatology,Puyang Central Hospital,Puyang,Henan Province 457600 China)

机构地区：[1]河南省濮阳市台前县夹河中心乡卫生院皮肤科,河南濮阳457600 [2]河南省濮阳市中医院皮肤科,河南濮阳457600

出　　处：《中国药物滥用防治杂志》2021年第2期239-242,254,共5页Chinese Journal of Drug Abuse Prevention and Treatment

摘　　要：目的:调查不同分型银屑病患者的诊疗相关药物使用情况,为银屑病的合理治疗提供数据支持。方法:对2018年2月—2020年6月就诊于该院的329例银屑病患者进行调查,依据患者银屑病分型进行分组,比较不同分型患者性别、年龄、病程、复发次数、用药种类等信息,并采集患者超疗程应用率及重金属中毒情况。结果:不同分型病程、复发次数、用药种类、用药时间超长、重金属中毒时间比较,差异有统计学意义(P<0.05);银屑病主要以糖皮质激素、维A酸类治疗为主。从药物使用方面看,糖皮质激素、维A酸类、润肤剂(外用)超疗程应用率高。重金属中毒发生率从大到小依次为:关节病型组、红皮病组、脓疱型组、寻常型组,比较差异有统计学意义(P<0.05)。结论:银屑病分型不同,用药差别较大,用药方面需重视疗程治疗,尤其是糖皮质激素长期应用导致皮损复发,免疫功能紊乱等,加重疾病负担,同时需要重视对重金属中毒的识别,加强银屑病的科学治疗宣传力度。Objective:To observe the status of drug abuse related to diagnosis and treatment of patients with psoriasis,and to provide data support for the reasonable treatment of psoriasis.Methods:A survey of 329 patients with psoriasis in the hospital from February 2018 to June 2020 was conducted.The patients were grouped according to their psoriasis types,and the gender,age,course of disease,number of relapses,and medications of different types of patients were compared,and patients’over-treatment application rate and heavy metal poisoning were collected.Results:There were statistically significant differences among different types of disease course,recurrence times,medication types,long medication time,and heavy metal poisoning time(P<0.05).Psoriasis was mainly treated with glucocorticoids and tretinoin.From the perspective of drug abuse,glucocorticoids,tretinoin,and emollients(for external use)had a high application rate for over-treatment.The incidence of heavy metal poisoning in descending order was:arthropathy group,erythroderma group,pustular group,and vulgaris group.The difference was statistically significant(P<0.05).Conclusion:The types of psoriasis are different,and the medications vary greatly.As for the medication,it needs to pay attention to the course of treatment,especially the long-term use of glucocorticoids leads to recurrence of skin lesions and immune dysfunction,which increase the burden of the disease.At the same time,it is necessary to pay attention to the identification of heavy metal poisoning,strengthen the publicity of scientific treatment of psoriasis.

关 键 词：银屑病 药物 糖皮质激素 免疫抑制剂 

分 类 号：R95[医药卫生—药学]