血清中4种天疱疮抗体在天疱疮诊断及鉴别诊断中的价值  

The role of four serum pemphigus antibodies in the diagnosis and differentiation of pemphigus

作　　者：李云珍[1] 李玲[1] 刘勇[1] 姚少濠 LI Yunzhen;LI Ling;LIU Yong;YAO Shaohao(Guangzhou Kingmed Center For Clinical Laboratory,Guangzhou,Guangdong 510005,China)

机构地区：[1]广州金域医学检验中心,广东广州510005

出　　处：《检验医学与临床》2021年第10期1398-1400,共3页Laboratory Medicine and Clinic

摘　　要：目的探讨4种天疱疮抗体[抗桥粒芯蛋白1抗体、抗桥粒芯蛋白3抗体、大疱性类天疱疮(BP)180抗体、BP 230抗体]在天疱疮的诊断和鉴别诊断中的临床意义。方法选取该中心2018年6月至2020年7月880例临床疑为"天疱疮"患者的标本,采用酶联免疫吸附试验检测4种天疱疮抗体并分析检测结果。结果 880例标本中4种天疱疮抗体阳性率为63.86%(562/880),男性和女性4种天疱疮抗体阳性率比较,差异无统计学意义(P>0.05)。BP阳性率(30.23%)>寻常型天疱疮(PV)(16.02%)>落叶型天疱疮(PF)(11.02%)>PV+BP(3.64%)>PF+BP(2.95%),BP阳性率最高,PF+BP阳性率最低。除PV+BP和PF+BP阳性率差异无统计学意义(P>0.05)外,其余两两比较,差异均有统计学意义(P<0.05)。BP阳性率随年龄增高而递增(P<0.05),其中>60岁组BP阳率(44.07%)最高。<40岁组和40~60岁组PV阳性率比较,差异无统计学意义(P>0.05),40~60岁组和>60岁组、<40岁组和>60岁组PV阳性率比较,差异均有统计学意义(P<0.05),40~60岁组PV阳性率(22.22%)最高,其次是<40岁组(20.99%)。<40岁组和40~60岁组PF阳性率比较,差异无统计学意义(P>0.05),40~60岁组和>60岁组、<40岁组和>60岁组PF阳性率比较,差异均有统计学意义(P<0.05),40~60岁PF阳性率(17.78%)最高,其次是<40岁组(11.66%)。结论 4种天疱疮抗体在天疱疮诊断及鉴别诊断中有重要参考价值。Objective To investigate the clinical role of pemphigus antibodies[anti-desmosomein 1 antibody,anti-desmosomein 3 antibody,bullous pemphigoid(BP)180 antibody,BP 230 antibody]in the diagnosis of pemphigus.Methods A total of 880 cases with suspected diagnosis of"pemphigoid"admitted in the center from June 2018 to July 2020 were selected to detect for four pemphigus antibodies by enzyme linked immunosorbent assay,and the test results were analyzed.Results The positive rate of 4 kinds of pemphigus antibodies in 880 samples was 63.86%(562/880).There was no significant difference in the positive rate of four kinds of pemphigus antibodies between male and female(P>0.05).The positive rate from high to low was BP(30.23%)>pemphigus vulgaris(PV)(16.02%)>pemphigus foliaceus(PF)(11.02%)>PV+BP(3.64%)>PF+BP(2.95%).The positive rate of BP was the highest,and the positive rate of PF+BP was the lowest,except for the difference between PV+BP and PF+BP,the differences between the two were statistically significant(P<0.05).The positive rate of BP increased with age(P<0.05),the positive rate of BP in>60 years old group was the highest(44.07%).There was no significant difference in PV positive rate between<40 years old group and 40-60 years old group(P>0.05).There were significant differences in PV positive rate between 40-60 years old group and>60 years old group,<40 years old group and>60 years old group(P<0.05).The highest PV positive rate was 22.22%in the 40-60 year old group,followed by<40 years old group(20.99%).There was no significant difference in the positive rate of PF between<40 years old group and 40-60 years old group(P>0.05),while there were significant differences in the positive rate of PF between 40-60 years old group and>60 years old group,<40 years old group and>60 years old group(P<0.05).The positive rate of PF in 40-60 years old group(17.78%)was the highest,followed by<40 years old group(11.66%).Conclusion These four pemphigus antibodies provide important reference for the diagnosis and differentiation of pemphigu

关 键 词：天疱疮抗体 寻常天疱疮 落叶型天疱疮 大疱性类天疱疮 

分 类 号：R446.6[医药卫生—诊断学] R751[医药卫生—临床医学]