伊布利特与胺碘酮序贯治疗对长程持续性及永久性心房颤动患者转复成功率、心功能的影响  

Effects of Sequential Therapy with Ibutilide and Amiodarone on Conversion Success Rate and Cardiac Function in Treatment of Patients with Long-standing Persistent and Permanent Atrial Fibrillation

作　　者：赵荣诚[1] 韩佳[1] ZHAO Rong-cheng;HAN Jia(The First Department of Cardiology,Central Hospital of Cangzhou City,Cangzhou,Hebei 061001,China)

机构地区：[1]沧州市中心医院心血管内一科,河北沧州061001

出　　处：《解放军医药杂志》2021年第5期88-92,共5页Medical & Pharmaceutical Journal of Chinese People’s Liberation Army

基　　金：沧州市科学技术研究与发展指导计划项目(172302089)。

摘　　要：目的探讨伊布利特与胺碘酮序贯治疗对长程持续性及永久性心房颤动患者转复成功率、心功能的影响。方法选取2018年3月—2019年11月我院收治的76例长程持续性及永久性心房颤动患者,将其中采用伊布利特治疗的38例纳入对照组,将采用伊布利特与胺碘酮序贯治疗的38例纳入观察组,比较2组转复成功率、心功能指标、炎性因子水平及不良反应发生情况。结果观察组转复成功率略高于对照组,但差异无统计学意义(P>0.05)。治疗后,观察组舒张早期充盈峰速度(E峰)、舒张晚期充盈峰速度(A峰)、左心室舒张末期直径(LVEDD)、左心室射血分数(LVEF)水平和对照组LVEDD、LVEF水平均较治疗前改善,且观察组E峰、A峰、LVEDD、LVEF水平均高于对照组,差异均有统计学意义(P<0.05或P<0.01)。治疗后,2组超敏C反应蛋白、白细胞介素-6及N末端脑钠肽前体水平均降低,且观察组降低程度更大,差异有统计学意义(P<0.05或P<0.01)。2组不良反应发生率比较差异无统计学意义(P>0.05),但观察组不良反应持续时间明显短于对照组(P<0.05)。结论长程持续性及永久性心房颤动患者给予伊布利特与胺碘酮序贯治疗,能够一定程度提高转复成功率,纠正炎症状态,改善心功能及预后,且安全性良好。Objective To investigate effects of sequential therapy with Ibutilide and Amiodarone on conversion success rate and cardiac function in treatment of patients with long-term persistent and permanent atrial fibrillation(AF).Methods A total of 76 patients with long-term persistent and permanent AF admitted during March 2018 and November 2019 were selected.Of them,38 patients who had treated with Ibutilide were selected as control group,while other 38 patients who had treated with sequential therapy with Ibutilide and Amiodarone were selected as observation group.Conversion success rate,cardiac function indexes,inflammatory factor levels and incidence rate of adverse reactions were compared in two groups.Results Conversion success rate in observation group was slightly higher than that in control group,but the difference was not statistically significant(P>0.05).After treatment,values of early diastolic filling velocity(E peak),late diastolic filling velocity(A peak),left ventricular end diastolic diameter(LVEDD)and left ventricular ejection fraction(LVEF)levels in observation group,and LVEDD and LVEF levels in control group were significantly improved compared with those before treatment,and levels of E peak,A peak,LVEDD and LVEF in observation group were significantly higher than those in control group(P<0.05 or P<0.01).After treatment,levels of high-sensitivity C-reactive protein,interleukin-6 and N-terminal pro brain natriuretic peptide in two groups were decreased,and the decrease degrees in observation group were significantly greater(P<0.05 or P<0.01).There was no significant difference in incidence rate of adverse reactions in two groups(P>0.05),but duration of adverse reactions in observation group was significantly shorter than that in control group(P<0.05).Conclusion Sequential therapy with Ibutilide and Amiodarone in treatment of patients with long-term persistent and permanent atrial fibrillation may improve conversion success rate in a certain degree,correct inflammatory state,improve cardiac function a

关 键 词：心房颤动 伊布利特 胺碘酮 序贯治疗 左心室射血分数 白细胞介素6 药物毒性 

分 类 号：R541.75[医药卫生—心血管疾病]