α1受体阻滞剂在输尿管结石中的研究进展  

Research progress ofα1 receptor blockers in ureteral calculi

作　　者：雷容 刘杨文易 张克 颜汝平[1] LEI Rong;LIU-YANG Wenyi;ZHANG Ke;YAN Ruping(Department of Urology Surgery,the Second Affiliated Hospital of Kunming Medical University,Yunnan Provincial Urology Surgery Research Institute,Yunnan,Kunming 650000,China)

机构地区：[1]昆明医科大学第二附属医院泌尿外科,云南省泌尿外科研究所,云南昆明650000

出　　处：《中国医药科学》2021年第6期31-33,46,共4页China Medicine And Pharmacy

基　　金：云南省科学技术厅-昆明医科大学联合专项(2017FE467-061);昆明医科大学研究生创新基金(2019S041)。

摘　　要：输尿管结石是泌尿外科常见的疾病,其发病率高、发病时患者疼痛剧烈难耐。近年来研究发现输尿管上有丰富的α1受体,其阻滞剂能有效抑制输尿管的收缩,缓解输尿管痉挛,可用于输尿管结石的治疗。本文就α1受体阻滞剂在输尿管结石中的应用情况做一综述,包括药物排石治疗、体外震波碎石(ESWL)后的辅助排石以及在输尿管结石围手术期中的应用。Ureteral calculi are common diseases in department of urology surgery.The incidence of this disease is high,andat the time of onset,the patient suffers severe pain which is intolerable.In recent years,it has been found that there are abundantα1 receptors in the ureter,and its blockers can effectively inhibit ureteral contraction and relieve ureteral spasm,which can be applied for the treatment of ureteral calculi.The application ofα1 receptor blockers in ureteral calculi,including drug lithotripsy treatment,assisted lithotripsy after extracorporeal shock wave lithotripsy(ESWL),and application in perioperative period of ureteral calculi was reviewed in this paper.

关 键 词：Α1受体阻滞剂 输尿管结石 药物排石治疗 无管化 双J管综合征 

分 类 号：R693.4[医药卫生—泌尿科学]