聚乙烯醇/海藻酸钠/黄连素医用敷料制备及其性能  

Preparation and performance of polyvinyl alcohol/sodium alginate/berberine medical dressing

作　　者：王春红[1] 李明[1] 龙碧旋 才英杰[2] 王利剑 左祺 WANG Chunhong;LI Ming;LONG Bixuan;CAI Yingjie;WANG Lijian;ZUO Qi(School of Textile Science and Engineering, Tiangong University, Tianjin 300387, China;College of Textile and Garments, Hebei University of Science and Technology, Shijiazhuang, Hebei 050080, China)

机构地区：[1]天津工业大学纺织科学与工程学院,天津300387 [2]河北科技大学纺织与服装学院,河北石家庄050080

出　　处：《纺织学报》2021年第5期16-22,共7页Journal of Textile Research

基　　金：国家自然科学基金项目(11802205)。

摘　　要：为提高聚乙烯醇(PVA)/海藻酸钠(SA)医用敷料的抗菌性和耐水性能,采用黄连素(BR)为天然抗菌剂负载在医用敷料上,通过静电纺丝法制备PVA/SA/BR纳米纤维膜,并在氯化钙无水乙醇溶液中进行交联处理,对PVA/SA/BR纳米纤维膜的化学结构、抗菌性能、吸液性能以及力学性能进行表征与分析。结果表明:BR负载在PVA/SA纳米纤维上形成明显串珠,且与PVA/SA结合良好,氯化钙交联处理后PVA/SA/BR纳米纤维膜由网状变为平滑膜状;当BR质量分数为6%时,PVA/SA/BR纳米纤维膜断裂强度为1.76 MPa,其对大肠杆菌和金黄色葡萄球菌的抑菌率分别为99.41%、97.89%;当氯化钙质量分数为4%,交联时间为4 h时,PVA/SA/BR纳米纤维膜的断裂强度为4.17 MPa,吸液倍率为1257%。In order to improve the antibacterial and water resistance of polyvinyl alcohol(PVA)/sodium alginate(SA)medical dressings,berberine(BR)was used as a natural antibacterial agent to load on the medical dressing.The PVA/SA/BR nanofiber membrane was prepared by electrostatic spinning,and the membrane was cross-linked in calcium chloride absolute ethanol solution.The chemical structure,antibacterial performance,liquid absorption and mechanical properties of the PVA/SA/BR nanofiber membrane were characterized and analyzed.The results show obvious beads of BR in PVA/SA nanofiber,which combine well with PVA/SA.After cross-linking with calcium chloride,the PVA/SA/BR nanofiber membrane changes from mesh to smooth membrane.When the mass fraction of berberine is 6%,the breaking strength of the PVA/SA/BR nanofiber membrane is 1.76 MPa,and the antibacterial rates for Escherichia coli and Staphylococcus aureus are 99.41%and 97.89%repspectively.When the mass fraction of calcium chloride is 4%and the cross-linking time is 4 h,the breaking strength of the PVA/SA/BR nanofiber membrane is 4.17 MPa and the liquid absorption rate is 1257%.

关 键 词：医用敷料 黄连素 氯化钙交联 抗菌性 耐水性能 纳米纤维膜 

分 类 号：TQ340.64[化学工程—化纤工业]