六味地黄汤加味联合心肺康复训练对COPD稳定期患者运动耐量血清IL-6 IL-8 Cys-C水平的影响  

Effects of Modified Liuwei Dihuang Decoction Combined with Cardiopulmonary Rehabilitation Training on Exercise Tolerance,Serum IL-6 IL-8 and Cys-C Levels in Patients with Stable COPD

作　　者：郑俊[1] 黄培[1] 武彩花 ZHENG Jun;HUANG Pei;WU Caihua(Wuhan Hospital of Integrated Traditional Chinese and Western Medicine, Hubei Wuhan 430022, China)

机构地区：[1]湖北省武汉市中西医结合医院针灸科,湖北武汉430022

出　　处：《河北医学》2021年第5期767-772,共6页Hebei Medicine

基　　金：湖北省卫生和计划生育委员会科研项目,(编号:WJ2017F013);湖北省知识创新专项(自然科学基金),(编号:2016CFB301)。

摘　　要：目的:探讨六味地黄汤加味联合心肺康复训练对慢性阻塞性肺疾病(COPD)稳定期患者运动耐量、血清白细胞介素-6(IL-6)、白细胞介素-8(IL-8)、胱抑素C(Cys-C)水平的影响。方法:选择2019年5月至2020年5月武汉市中西医结合医院收治的192例COPD稳定期患者,采用随机数字表法以1∶1简单随机分为观察组、对照组,各96例。对照组使用常规西医治疗,观察组予以六味地黄汤加味联合心肺康复训练。比较两组临床疗效、治疗前后症状改善情况、运动耐量、肺功能、血清IL-6、IL-8、Cys-C水平。结果:观察组临床治疗总有效率94.79%高于对照组86.46%(P<0.05);治疗后,两组中医症状积分明显降低,6MWT明显升高(P<0.05),观察组中医症状积分、6MWT治疗前后差值高于对照组(P<0.05);治疗后,两组用力肺活量(FVC)、第1s用力呼气容积(FEV1)、每分钟最大通气量(MVV)、FEV1/FVC明显升高(P<0.05),且观察组FVC、FEV1、MVV、FEV1/FVC治疗前后差值高于对照组(P<0.05);治疗后,两组IL-6、IL-8、Cys-C水平明显降低(P<0.05),观察组IL-6、IL-8、Cys-C水平治疗前后差值高于对照组(P<0.05)。结论:六味地黄汤加味联合心肺康复训练能提升COPD稳定期患者的临床疗效,改善运动耐量,缓解临床症状,促进肺功能恢复,降低血清IL-6、IL-8、Cys-C水平。Objective:To explore the effects of modified Liuwei Dihuang Decoction combined with cardiopulmonary rehabilitation training on exercise tolerance,serum interleukin-6(IL-6),interleukin-8(IL-8)and cystatin-C(Cys-C)levels in patients with stable chronic obstructive pulmonary disease(COPD).Methods:192 patients with stable COPD admitted to the hospital from May 2019 to May 2020 were enrolled and divided into observation group and control group by random number table method,96 cases in each group.The control group was treated with routine western medicine,while observation group was given modified Liuwei Dihuang Decoction combined with cardiopulmonary rehabilitation training.The clinical curative effect,scores of TCM symptoms,exercise tolerance,pulmonary function,serum IL-6,IL-8 and Cys-C levels before and after treatment were compared between the two groups.Results:The total response rate of clinical treatment in observation group was higher than that in control group(94.79%vs 86.46%)(P<0.05).After treatment,scores of TCM symptoms were significantly decreased,while 6-min walk test(6MWT)was significantly increased in both groups(P<0.05).The difference values of the above two indexes before and after treatment in observation group were higher than those in control group(P<0.05).After treatment,forced vital capacity(FVC),forced expiratory volume in 1 second(FEV1),maximum ventilation per minute(MVV)and FEV1/FVC were significantly increased in both groups(P<0.05).The difference values of the above four indexes before and after treatment in observation group were higher than those in control group(P<0.05).After treatment,levels of IL-6,IL-8 and Cys-C were significantly decreased in both groups(P<0.05).The difference values of the above three indexes before and after treatment in observation group were higher than those in control group(P<0.05).Conclusion:The modified Liuwei Dihuang Decoction combined with cardiopulmonary rehabilitation training can improve the clinical curative effect on patients with stable COPD,improve ex

关 键 词：运动耐量 六味地黄汤 慢性阻塞性肺疾病 心肺康复训练 

分 类 号：R56[医药卫生—呼吸系统]