野蚕豆根总环烯醚萜苷对非酒精性脂肪肝大鼠肝脏功能的影响  

Effects of Total Iridoid Glycosides from Centranthera grandiflora on the Liver Function of Rats with a Nonalcoholic Fatty Liver Disease

作　　者：李莉 单蕊 陈燕 朱瑛 杜冰 李海宁 姚政 LI Li;SHAN Rui;CHEN Yan;ZHU Ying;DU Bing;LI Haining;YAO Zheng(Yunnan University of Traditional Chinese Medicine,Kunming 650500,China;Chongqing Kaizhou TCM Hospital,Chongqing 405400,China;Xuancheng Central Hospital of Anhui Province,Xuancheng 242000,China)

机构地区：[1]云南中医药大学,云南昆明650500 [2]重庆市开州区中医院,重庆405400 [3]安徽省宣城市中心医院,安徽宣城242000

出　　处：《中国民族民间医药》2021年第9期25-28,共4页Chinese Journal of Ethnomedicine and Ethnopharmacy

基　　金：国家自然科学基金(81860812);云南省应用基础研究-中医联合专项[2017FF116(-021)]。

摘　　要：目的:观察野蚕豆根中总环烯醚萜苷对非酒精性脂肪肝大鼠肝脏功能的影响。方法:采用高脂饲料喂养4周建立非酒精性脂肪肝大鼠模型,给药4周后,全自动生化仪检测大鼠血清生化,HE染色观察肝脏病理情况。结果:血清生化结果显示,总环烯醚萜苷可以降低非酒精性脂肪肝大鼠血清甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)水平和丙氨酸氨基转移酶(ALT)活性,升高高密度脂蛋白胆固醇(HDL-C)水平。病理结果显示:总环烯醚萜苷组脂肪空泡较模型组变小变少。结论:动物实验表明野蚕豆根中的总环烯醚萜苷成分无肝毒性,且有一定保肝护肝、降脂作用。Objective To observe the effect of total iridoid glycosides in Centranthera grandiflora on liver function in non-alcoholic fatty liver rats.Methods The rats were fed with high-fat diet for 4 weeks to establish a non-alcoholic fatty liverrat model.After 4 weeks of administration,the automatic biochemical analyzer was used to detect the serum biochemistry of the rats,and HE staining was used to observe the liver pathology.Results Total iridoid glycosides reduced the levels of triglyceride(TG),low density lipoprotein cholesterol(LDL-C)and alanine aminotransferase(ALT)activity,and increased the level of high density lipoprotein cholesterol(HDL-C)in rats with nonalcoholic fatty liver disease.Pathological results showed that fatty vacuoles in total iridoid glycosides group were smaller and less than those in model group.Conclusion The total iridoid glycosides in Centranthera grandiflora had no hepatotoxicity,and had some hepatoprotective and lipid-lowering effects.

关 键 词：野蚕豆根 总环烯醚萜苷 非酒精性脂肪肝 

分 类 号：R285.1[医药卫生—中药学]