正交试验优选制洋金花的炮制工艺研究  

Study on Processing Technology of Fried Daturae Flos by Orthogonal Experiment

作　　者：夏永严 李娅 秦昆明 杨超[4] 蔡宝昌 金俊杰[2,3] XIA Yongyan;LI Ya;QIN Kunming;YANG Chao;CAI Baochang;JIN Junjie(Department of pharmacy,the Affiliated Zhangjiagang Hospital of Soochow University,Suzhou 215600,China;Nanjing Haichang Chinese Medicine Corporation,Nanjing 210061,China;Nanjing Haiyuan Prepared Slices of Chinese Crude Drugs Co.Ltd,Nanjing 210061,China;Engineering Center of State Ministry of Education for Standardization of Chinese Medicine Processing,Nanjing University of Chinese Medicine,Nanjing 210023,China)

机构地区：[1]苏州大学附属张家港医院药剂科,江苏苏州215600 [2]南京海昌中药集团有限公司,江苏南京210061 [3]南京海源中药饮片有限公司,江苏南京210061 [4]南京中医药大学国家教育部中药炮制规范化及标准化工程研究中心,江苏南京210023

出　　处：《中国民族民间医药》2021年第9期58-62,共5页Chinese Journal of Ethnomedicine and Ethnopharmacy

基　　金：江苏省科技成果转化专项资金项目(BA2018002);南京市科技计划项目(201812021)。

摘　　要：目的:对制洋金花的炮制工艺进行优化。方法:以东莨菪碱含量和水分含量的综合评分为指标,采用正交试验考察生姜打汁后加水量(A)、闷润时间(B)、炒制温度(C)、炒制时间(D)4项指标,确定制洋金花的最佳炮制工艺。结果:筛选出制洋金花的最佳工艺参数为生姜打汁后加水量(A)3倍,闷润时间(B)40 min,炒制温度(C)270~300℃、炒制时间(D)5 min,炮制后的制洋金花有酒香气和微姜味。结论:优选得到的制洋金花炮制工艺稳定可行,为更好地控制制洋金花的质量提供科学依据。Objective To study the processing technology of Fried Daturae Flos by orthogonal experiment.Methods Taking scopolamine and water content as the evaluation indexes,the effects of ginger water added(A),wetting time(B),frying temperature(C)and frying time(D)on the processing technology were investigated by orthogonal experiment.Finally determine the best processing technology for Fried Daturae Flos.Results The optimum technological parameters for fried Daturae Flos are 3 times of ginger water added(A),40 min of wetting time(B),270~300℃of frying temperature(C)and 5 min of frying time(D).The processed Daturae Flos smell has aroma of wine and slight ginger.Conclusion The optimal process of fried Daturae Flos is stable and feasible,which can provide scientific basis for better control of it’s quality.

关 键 词：制洋金花 炮制工艺 东莨菪碱 正交试验 

分 类 号：R283[医药卫生—中药学]