蓬莱葛枝叶的生物碱类成分研究  

Alkaloid constituents from twigs and leaves of Gardneria multiflora

作　　者：桑晨晨 李紫薇 庞熙 邹雪怡 叶文才[1,2] 张晓琦 SANG Chen-chen;LI Zi-wei;PANG Xi;ZOU Xue-yi;YE Wen-cai;ZHANG Xiao-qi(Institute of Traditional Chinese Medicine&Natural Products,Guangdong Engineering Research Center for Modernization of TCM,College of Pharmacy,Jinan University,Guangzhou 510632,China;NMPA Key Laboratory for Quality Evaluation of TCM(Traditional Chinese Patent Medicine),Guangzhou 510632,China)

机构地区：[1]暨南大学药学院中药及天然药物研究所,广东省现代中药工程技术研究中心,广东广州510632 [2]国家药品监督管理局中成药质量评价重点实验室,广东广州510632

出　　处：《中草药》2021年第8期2210-2216,共7页Chinese Traditional and Herbal Drugs

基　　金：国家自然科学基金资助项目(U1801287);国家自然科学基金资助项目(82073712);广东省科技计划项目(2018B020207008,2020B1111110004)。

摘　　要：目的研究蓬莱葛Gardneria multiflora枝叶的化学成分。方法采用硅胶、ODS、Sephadex LH-20和HPLC等色谱方法进行分离纯化,并根据化合物的理化性质及波谱学数据鉴定其化学结构。结果从蓬莱葛枝叶中分离得到13个生物碱类化合物,分别鉴定为antirhine 4α-oxide (1)、geissoschizol (2)、melosline E (3)、土波台文碱(4)、tubotaiwine N-oxide(5)、pyridinium (6)、melosline B (7)、N-甲基巴婆碱(8)、venoterpine (9)、肉桂酰胺(10)、lyaloside (11)、异长春花苷内酰胺(12)、柯诺辛碱(13)。结论化合物1~13均为首次从该植物中分离得到。Objective To study the chemical constituents of Gardneria multiflora. Methods The chemical constituents were isolated from the total alkaloids of the twigs and leaves of G. multiflora by using silica gel, ODS, Sephadex LH-20, and HPLC chromatographic methods. The chemical structures were identified based on their physical and chemical properties and spectroscopic methods. Results Thirteen alkaloids were isolated and identified as antirhine 4α-oxide(1), geissoschizol(2), melosline E(3), tubotaiwine(4), tubotaiwine N-oxide(5), pyridinium(6), melosline B(7), N-methylasimilobine(8), venoterpine(9), cinnamamide(10), lyaloside(11), strictosamide(12), corynoxine(13), respectively. Conclusion All compounds are obtained from this plant for the first time.

关 键 词：蓬莱葛 马钱科 生物碱 土波台文碱 异长春花苷内酰胺 柯诺辛碱 

分 类 号：R284.1[医药卫生—中药学]