中药缓控释制剂的研究进展  

Research progress on sustained and controlled-release preparation of traditional Chinese medicine

作　　者：董玉洁 蒋沅岐 陈金鹏 刘毅[2,3,4] 周福军 田成旺[2,3,4] 陈常青 DONG Yu-jie;JIANG Yuan-qi;CHEN Jin-peng;LIU Yi;ZHOU Fu-jun;TIAN Cheng-wang;CHEN Chang-qing(Tianjin University of Traditional Chinese Medicine,Tianjin 300193,China;Tianjin Institute of Pharmaceutical Research,Tianjin 300462,China;Tianjin Key Laboratory of Quality Marker of Traditional Medicine,Tianjin 300462,China;State Key Laboratory of Drug Delivery and Pharmacokinetics,Tianjin 300462,China)

机构地区：[1]天津中医药大学,天津300193 [2]天津药物研究院,天津300462 [3]天津市中药质量标志物重点实验室,天津300462 [4]释药技术与药代动力学国家重点实验室,天津300462

出　　处：《中草药》2021年第8期2465-2472,共8页Chinese Traditional and Herbal Drugs

基　　金：国家重点研发计划项目(2018YFC170810203);重大新药创制专项(2019ZX09201-005)。

摘　　要：我国中医药发展历史悠久,很早便有了缓控释技术的雏形。现代缓控释制剂作为第3代药物制剂,具有服药周期短、药物作用时间长、安全性高、疗效好等显著的优势,已成为中药制剂领域的研究热点。中药缓控释制剂以缓释片、缓释胶囊、微囊微球及凝胶剂等剂型研究较多,结合相关文献对现代缓控释制剂的研究概况、缓控释技术在中药领域的应用及其价值和局限性进行综述,以期为中药缓控释制剂的开发提供参考。Traditional Chinese medicine(TCM)has a long history in China,and has existed the embryonic form of sustained and controlled release technology for a long time.As the third generation of pharmaceutical preparations,modern sustained and controlled release preparations have obvious advantages such as short drug cycle,long drug action time,high safety and good efficacy,etc.Modern sustained and controlled release preparations have become the research hotspot in the field of TCM preparations.There are many studies on formulations of TCM sustained-release tablets,sustained-release capsules,microspheres and gels.In this paper,research progress on modern sustained and controlled release preparation,the application of sustained and controlled-release technology in the field of TCM,as well as its value and limitations are reviewed,aiming to provide reference for the development of sustained and controlled release preparations of TCM.

关 键 词：中药 缓释制剂 控释制剂 缓控释制剂 局限性 

分 类 号：R283.3[医药卫生—中药学]