糖皮质激素诱导性股骨头坏死患者影像学分期与血清PAI-1水平的关系  

Relationship between imaging staging and serum PAI-1 level in glucocorticoid-induced necrosis of femoral head

作　　者：王国强 胡春峰 WANG Guo-qiang;HU Chun-feng(Department of Imaging,the Afiliated Hospital of Xuzhou Medical Unizersity,Xuzhou,Jiangsu 221003,China;不详)

机构地区：[1]徐州医科大学附属医院影像科,江苏徐州221003 [2]徐州医科大学附属邳州医院CT室,江苏徐州221300

出　　处：《中国临床研究》2021年第4期506-508,共3页Chinese Journal of Clinical Research

基　　金：徐州医科大学校级科研基金(2018KJ23)。

摘　　要：目的通过检测不同影像学分期的糖皮质激素诱导性股骨头坏死(SONFH)患者血清中1型纤溶酶原激活物抑制剂(PAI-1)水平变化,探讨血清PAI-1水平与SONFH的关系,以及PAI-1在不同X线影像学分期SONFH的意义。方法选取2018年6月至2019年5月于徐州医科大学附属邳州医院就诊的SONFH患者75例作为观察组,国际骨循环学会(ARCO)分期:Ⅱ期25例、Ⅲ期25例、Ⅳ期25例,并随机选取75例健康体检者作为对照组。使用ELISA法检测两组对象血清PAI-1水平。结果观察组血清PAI-1水平显著高于对照组[(21.87±2.39) mg/L vs(12.52±1.22) mg/L,P<0.05];但不同影像学分期的SONFH患者间,血清PAI-1水平差异无统计学意义(P>0.05)。股骨头未塌陷与塌陷SONFH患者间,血清PAI-1水平差异无统计学意义(P>0.05)。结论 SONFH患者血清PAI-1水平较正常人群明显增高,可做为SONFH临床诊断和治疗的一项参考指标。但是在SONFH患者中,PAI-1水平与X线影像学分期无明显相关,且与股骨头塌陷与否无关。Objective To investigate the relationship between serum plasminogen activator inhibitor 1(PAI-1) and imaging of steroid(glucocorticoid)-induced onecrosis of femoral head(SONFH) in different X-ray imaging stages and their significance.Methods A total of 75 SONFH patients treated at Pizhou Hospital Affiliated to Xuzhou Medical University from June 2018 to May 2019 were selected as observation group, including 25 cases of stage Ⅱ,25 cases of stage Ⅲ and 25 cases of stage Ⅳ based on Association Research Circulation Osseous(ARCO) staging.During the same period, 75 healthy persons were randomly selected as control group.The serum PAI-1 levels were detected by enzyme-linked immunosorbent assay(ELISA) and compared between two groups.Results The serum PAI-1 level in observation group was significantly higher than that in control group [(21.87±2.39) mg/L vs(12.52±1.22) mg/L,P<0.05].However, there were no significant differences in serum PAI-1 level among SONFH patients with different imaging stages(including no collapse and collapse of femoral head)(all P>0.05).Conclusions In the patients with SONFH,the serum PAI-1 level increases significantly, which can be used as a reference index for clinical diagnosis and treatment of SONFH.However, PAI-1 level is not obviously correlated with X-ray imaging staging and femoral head collapse or not.

关 键 词：股骨头坏死 糖皮质激素诱导 1型纤溶酶原激活物抑制剂 影像学 国际骨循环学会分期 

分 类 号：R581.8[医药卫生—内分泌]