绞股蓝中1个新的葫芦烷型皂苷类化合物  

A new cucurbitane-type saponin from Gynostemma pentaphyllum

作　　者：娄云云 牟龙 黄亚萍 张健[3] 殷志琦 潘珂 LOU Yun-yun;MU Long;HUANG Ya-ping;ZHANG Jian;YIN Zhi-qi;PAN Ke(Department of Natural Medicinal Chemistry,School of Traditional Chinese Pharmacy,China Pharmaceutical University,Nanjing 211198,China;Department of TCMs Pharmaceuticals&State Key Laboratory of Active Components and Efficacy of Natural Medicines,School of Traditional Chinese Pharmacy,China Pharmaceutical University,Nanjing 210009,China;Laboratory of Translational Medicine,Jiangsu Provincial Academy of Traditional Chinese Medicine,Nanjing 210028,China)

机构地区：[1]中国药科大学中药学院天然药物化学系,江苏南京211198 [2]中国药科大学中药学院中药制药系&天然药物活性组分与药效国家重点实验室,江苏南京210009 [3]江苏省中医药研究院转化医学实验室,江苏南京210028

出　　处：《中草药》2021年第7期1872-1876,共5页Chinese Traditional and Herbal Drugs

基　　金：江苏省高校青蓝工程资助项目;大学生创新创业训练计划项目成果(202010316044S);2020年江苏省研究生科研创新计划(KYCX200676)。

摘　　要：目的对绞股蓝Gynostemma pentaphyllum的总皂苷提取物进行化学成分研究。方法综合应用多种色谱技术进行分离纯化,通过各种现代谱学技术对化合物进行结构鉴定。结果从绞股蓝的总皂苷提取物中分离得到2个葫芦烷型三萜皂苷类化合物,分别鉴定为葫芦素L-2-O-{[a-L-吡喃鼠李糖基-(1→2)][α-L-吡喃阿拉伯糖基-(1→3)]-β-D-吡喃葡萄糖基}-25-O-β-D-吡喃木糖苷(1)、葫芦素L-2-O-[α-L-吡喃鼠李糖基-(1→2)][a-L-吡喃阿拉伯糖基-(1→3)]-β-D-吡喃葡萄糖苷(2)。结论化合物1为1个新化合物,命名为绞股蓝葫芦皂苷A。Objective To further study the chemical constituents from the total saponin extract of Jiaogulan(Gynostemma pentaphyllum). Methods The chemical constituents of G. pentaphyllum were separated and purified by chromatographic methods and structurally elucidated by means of various spectroscopic techniques. Results Two cucurbitane-type saponins were isolated from the total saponin extract of G. pentaphyllum, and identified as cucurbitacin L-2-O-{[α-L-rhamnopyranosyl-(1→2)] [α-L-arabinopyranosyl-(1→3)]-β-D-glucopyranosyl}-25-O-β-D-xylopyranoside(1), cucurbitacin L-2-O-[a-L-rhamnopyranosyl-(1→2)] [α-L-arabinopyranosyl-(1→3)]-β-D-glucopyranoside(2). Conclusion Compound 1 is a new compound named cucurbitane-gypenoside A.

关 键 词：绞股蓝 绞股蓝属 葫芦烷型 三萜皂苷 绞股蓝葫芦皂苷A 葫芦素L-2-O-[α-L-吡喃鼠李糖基-(1→2)][α-L-吡喃阿拉伯糖基-(1→3)]-β-D-吡喃葡萄糖苷 

分 类 号：R284.1[医药卫生—中药学]