伤疼巴布贴治疗早中期膝骨关节炎的临床研究  

Observation of Clinical Efficacy of Shangteng Cataplasm on Early and Mid-Stage Knee Osteoarthritis

作　　者：钟传棋 吴斌[1,2] 杨功旭[1,2] 张清[1,2] 金军[1,2] ZHONG Chuanqi;WU Bin;YANG Gongxu;ZHANG Qing;JIN Jun(Hubei Provincial Hospital of Traditional Chinese Medicine,Wuhan 430061,China;Hubei Province Academy of Traditional Chinese Medicine,Wuhan 430074,China)

机构地区：[1]湖北省中医院,武汉430061 [2]湖北省中医药研究院

出　　处：《中国中医骨伤科杂志》2021年第4期35-38,共4页Chinese Journal of Traditional Medical Traumatology & Orthopedics

基　　金：湖北省自然科学基金面上项目(2017CFC836);湖北省中医院“五专建设”项目。

摘　　要：目的:探讨伤疼巴布贴对早中期膝骨关节炎的临床疗效及对患者外周血清中MMP-13和IL-1β的影响。方法:选择早中期膝骨关节炎患者80例,随机编码分为观察组和对照组治疗,每组各40例,对照组外用双氯芬酸钠贴剂治疗,观察组外用伤疼巴布贴治疗,治疗2周,观察治疗前后VAS评分、WOMAC指数及Lysholm膝关节评分变化,ELISA法测定治疗前后患者外周血清中MMP-13及IL-1β变化。结果:治疗期间两组无皮肤过敏等情况,对照组VAS评分及WOMAC指数治疗前后比较差异有统计学意义(P<0.05),观察组VAS评分、WOMAC指数及Lysholm膝关节评分治疗前后比较差异有统计学意义(P<0.05);组间比较,治疗后两组WOMAC指数及Lysholm膝关节评分差异有统计学意义(P<0.05);观察组治疗前后外周血清中MMP-13和IL-1β差异有统计学意义(P<0.05),治疗后组间IL-1β水平比较差异有统计学意义(P<0.05)。结论:伤疼巴布贴治疗早中期膝骨关节炎能较好减轻疼痛、改善症状,伤疼巴布贴治疗骨关节炎可能与降低MMP-13和IL-1β水平相关。Objective:To explore the clinical effect of Shangteng Cataplasm on early and mid-stage knee osteoarthritis and its influence on MMP-13 and IL-1β in peripheral serum of patients.Methods:Eighty patients with knee osteoarthritis were selected and randomly divided into observation and control group for treatment with 40 cases in each group.The control group was treated with diclofenac sodium patch, and the observation group was treated with Shangteng Cataplasm.VAS score, WOMAC index, Lysholm knee joint score before and after treatment were documented after 2 weeks’ treatment.MMP-13 and IL-1β in peripheral serum of patients before and after treatment were measured by ELISA.Results:Two groups revealed no skin allergies during the treatment period.Statistically significants of VAS score and WOMAC index were founded in control group before and after treatment(P<0.05).Statistically significants of VAS score, WOMAC index, and Lysholm knee joint score were founded in observation group before and after treatment(P<0.05).There were difference in WOMAC index and Lysholm knee score between the two groups(P<0.05).there were statistical differences in serum MMP-13 and IL-1β of the observation group before and after treatment(P<0.05).Conclusion:Shangteng cataplasm for knee osteoarthritis in early and mid-stage knee osteoarthritis can effectively relieve pain and improve symptoms, which may be related to the reduction of MMP-13 and IL-1β.

关 键 词：伤疼巴布贴 膝关节 骨性关节炎 基质金属蛋白酶-13 白介素-1Β 

分 类 号：R684.3[医药卫生—骨科学]