胸腰椎骨质疏松性骨折治疗后BMD、BGP变化的Meta分析  

Meta-analysis of changes of BMD and BGP after the treatment of thoracolumbar osteoporotic fractures

作　　者：张浩 王文瑀 王莉梅 班晓静 李贺楠 ZHANG Hao;WANG Wenyu;WANG Limei;BAN Xiaojing;LI He′nan(FAW General Hospital of Jilin Province, Changchun 130011, China)

机构地区：[1]吉林省一汽总医院,吉林长春130011

出　　处：《中国骨质疏松杂志》2021年第5期699-703,共5页Chinese Journal of Osteoporosis

基　　金：吉林省卫健委管理模式革新项目(2020G009)。

摘　　要：目的系统评价胸腰椎骨质疏松性骨折在接受复方骨肽注射液治疗后骨密度(bone mineral density,BMD)、骨钙素(bone gla protein,BGP)的变化。方法制定检索策略并检索目前国内外公开发表的中、英文数据库,应用Review Manager 5.3对纳入文献中所提取的数据资料进行分析。结果复方骨肽组与对照组相比,其治疗胸腰椎骨质疏松性骨折的总有效率显著高于后者(OR:7.51;95%CI:4.40~12.83;P<0.00001);其骨痛强度评分更低(WMD:-1.62;95%CI:-1.94~-1.29;P<0.00001)、骨密度值更高(WMD:0.04;95%CI:0.01~0.07;P<0.05)、血清骨钙素更高(WMD:2.01;95%CI:1.44~2.58;P<0.00001)、中度骨痛病例数更少(OR:0.32;95%CI:0.17~0.58;P<0.05)、重度骨痛病例数更少(OR:0.14;95%CI:0.06~0.32;P<0.00001),轻度骨痛病例数相对更多(OR:1.63;95%CI:0.38~6.98;P>0.05),但差异并无统计学意义。结论胸腰椎骨质疏松性骨折患者在接受复方骨肽治疗后,其骨密度、血清骨钙素等指标优于对照组,可缓解骨痛症状,具有积极的临床意义。Objective To systematically evaluate the changes of bone mineral density(BMD)and BGP in patients with thoracolumbar osteoporotic fractures after the treatment with compound osteopeptide injection.Methods The retrieval strategy was established and the Chinese and English databases published at home and abroad were searched.The data were extracted and analyzed with Review Manager 5.3.Results The total efficacy was significantly higher(OR:7.51;95%CI:4.40,12.83;P<0.00001),bone pain intensity score was lower(WMD:-1.62;95%CI:-1.94,-1.29;P<0.00001),BMD was higher(WMD:0.04;95%CI:0.01,0.07;P<0.05),the cases with moderate bone pain were more(OR:0.32;95%CI:0.17,0.58;P<0.05),the cases with severe bone pain were less(OR:0.14;95%CI:0.06,0.32;P<0.00001),serum osteocalcin was higher(WMD:2.01;95%CI:1.44,2.58;P<0.00001),and the cases with mild bone pain were more(OR:1.63;95%CI:0.38,6.98;P>0.05)in compound osteopeptide group than those in the control group.Conclusion BMD and serum osteocalcin in patients with thoracolumbar osteoporotic fractures treated with compound osteopeptide are better than those in the control group.The treatment relieves the symptom of bone pain and has positive clinical significance.

关 键 词：胸椎 腰椎 骨质疏松性骨折 骨密度 骨钙素 META分析 

分 类 号：R683.2[医药卫生—骨科学]