从中医“虚”论治原发性骨质疏松症与OPG/RANK/RANKL信号通路的相关性  

The relationship between the treatment of primary osteoporosis and OPG/RANK/RANKL signaling pathway based on“deficiency”of Chinese medicine

作　　者：郭宏刚 谢兴文 顾玉彪[4] 李宁[1] 李鼎鹏 施彦龙 苏积亮 丁聚贤 柳博 钱敏 GUO Honggang;XIE Xingwen;GU Yubiao;LI Ning;LI Dingpeng;SHI Yanlong;SU Jiliang;DING Juxian;LIU Bo;QIAN Min(Gansu University of Chinese Medicine, Lanzhou 730000;The Affiliated Hospital of Northwest University for Nationalities, Lanzhou 730000;The Second People’s Hospital of Gansu Province, Lanzhou 730000;Gansu Traditional Chinese Medicine Hospital, Lanzhou 730050, China)

机构地区：[1]甘肃中医药大学,甘肃兰州730000 [2]西北民族大学附属医院,甘肃兰州730000 [3]甘肃省第二人民医院,甘肃兰州730000 [4]甘肃省中医院,甘肃兰州730000

出　　处：《中国骨质疏松杂志》2021年第5期742-746,共5页Chinese Journal of Osteoporosis

基　　金：国家自然科学基金项目(81860864);中央引导地方科技发展专项项目-甘肃地区多发病防治能力提升创新平台项目;兰州市科技局社会发展项目(2016-3-102);甘肃省属科研院所基础条件建设专项(18JR2TA016);国家中医药管理局中医临床研究基地业务建设专项(JDZX2015080);甘肃省科技计划资助(20JR5RA129);甘肃省省级引导科技创新发展专项资金项目。

摘　　要：原发性骨质疏松症(primary osteoporosis,POP)是现代临床中常见的骨科疾病,其归属于中医学之“骨痿”“骨痹”“骨枯”等范畴。随着中医药事业的发展,中医学在POP的治疗中应用愈加广泛,且疗效显著,已受到学界的广泛认可。但遗憾的是,其缺乏现代研究理论依据的支撑。随着分子生物学的发展,OPG/RANK/RANKL信号通路的发现对中医学治疗此病具有重要意义。故笔者将从中医“虚”理论出发,并以中医学脏腑辨证理论为基础,借助现代分子生物学的研究成果OPG/RANK/RANKL信号通路,揭示中医治疗POP的OPG/RANK/RANKL信号通路表达机制,以期为中医学治疗POP提供科学理论依据。Primary osteoporosis(POP)is a common orthopedic disease in modern clinic,which belongs to the categories of“bone flaccidity”,“bone arthralgia”,and“bone dryness”in traditional Chinese medicine.With the development of Chinese medicine,Chinese medicine has been widely used in the treatment of POP.Its efficacy is remarkable,which has been widely recognized in academics.Unfortunately,it lacks the support by modern research theory.With the development of molecular biology,the discovery of OPG/RANK/RANKL signaling pathway is of great significance to the treatment of this disease with traditional Chinese medicine.Therefore,the authors reveal the OPG/RANK/RANKL signal pathway expression mechanism of treatment of POP with traditional Chinese medicine from the“deficiency”theory,and based on the syndrome differentiation theory of viscera in traditional Chinese medicine,and with the help of modern molecular biology research in OPG/RANK/RANKL signal pathway,in order to provide scientific theoretical basis for traditional Chinese medicine for the treatment of POP.

关 键 词：中医学 虚证 原发性骨质疏松症 OPG/RANK/RANKL信号通路 

分 类 号：R589.5[医药卫生—内分泌] R274.9[医药卫生—内科学]