间充质干细胞来源外泌体修复创伤性脊髓损伤  

Exosomes Derived from Mesenchymal Stem Cells Repairing Traumatic Spinal Cord Injury

作　　者：周丽 孔彦龙[1] 陶欣荣[1] ZHOU Li;KONG Yanlong;TAO Xinrong(Medical College of Anhui University of Science and Technology,Huainan Anhui 232001,China)

机构地区：[1]安徽理工大学医学院,安徽淮南232000

出　　处：《安徽理工大学学报（自然科学版）》2021年第1期75-80,共6页Journal of Anhui University of Science and Technology:Natural Science

基　　金：淮南市指导性科技计划资助项目(2020B026);安徽理工大学研究生创新基金资助项目(2019CX2070,2019CX2069)。

摘　　要：创伤性脊髓损伤能够引起严重的神经功能障碍,是一种严重影响生活质量的疾病,但是尚无有效的治疗方法。现有研究中发现间充质干细胞来源的外泌体具有和母细胞相似的生理作用,将外泌体应用于脊髓损伤的治疗中表现出令人满意的疗效,而且移植外泌体后尚未发现在移植干细胞中出现的致瘤等副作用,因此外泌体将会是脊髓损伤治疗中一个很有前景的策略。现将间充质干细胞来源外泌体在治疗创伤性脊髓损伤中的研究进展进行综述,分析目前存在的问题和未来的研究方向。Traumatic spinal cord injury,which will cause serious neurological dysfunction,is a disease that seriously affects the quality of life,but there are no effective treatments.In present studies,it has been found that the exosomes derived from mesenchymal stem cells have similar physiological effects to mother cells,and the application of such exosomes in the treatment of spinal cord injury shows satisfactory curative effect.Moreover,side effects such as tumorigenesis happened in transplanting stem cells have not been found in transplanting the exosomes until now,therefore this method of transplanting exosomes will be a promising strategy in therapy of spinal cord injury.Here is a review to analyze existing problems and future direction in research of exosomes derived from mesenchymal stem cells in the treatment of traumatic spinal cord injury.

关 键 词：间充质干细胞 外泌体 创伤性脊髓损伤 再生修复 

分 类 号：TP392.4[自动化与计算机技术—计算机应用技术]