多药耐药蛋白4在呼吸系统疾病中作用研究进展  

Multidrug resistance protein 4 in respiratory diseases

作　　者：郭慧 徐桂华 高笑宇 王潇 李媛 李倩[1] 孙德俊 GUO Hui;XU Gui-hua;GAO Xiao-yu;WANG Xiao;LI Yuan;LI Qian;SUN De-jun(Baotou Medical College,Inner Mongolia University of Science and Technology,Baotou,Inner Mongolia Autonomous Region 014000,China;Key Laboratory of National Health Commission for the Diagnosis&Treatment of COPD,the People’s Hospital of Inner Mongolia Autonomous Region,Hohhot,Inner Mongolia Autonomous Region 010000,China)

机构地区：[1]内蒙古科技大学包头医学院,内蒙古自治区包头014000 [2]国家卫生健康委慢阻肺诊治重点实验室,内蒙古自治区人民医院呼吸内科,内蒙古自治区呼和浩特010000

出　　处：《中华实用诊断与治疗杂志》2021年第4期420-422,共3页Journal of Chinese Practical Diagnosis and Therapy

基　　金：国家自然科学基金(81960013,81960427);中国医学科学院中央级公益性科研院所基本科研业务费专项资金资助项目(2019PT350001)。

摘　　要：多药耐药蛋白4是ATP结合盒转运蛋白C亚家族中的一员,可将多种内源性和外源性有机阴离子化合物泵出细胞。多药耐药蛋白4参与某些呼吸系统疾病的病理生理过程,包括肺癌、支气管哮喘和肺动脉高压等。本文就多药耐药蛋白4的结构、生物学功能及其在呼吸系统疾病中作用的研究进展作一综述。Multidrug resistance protein 4 is a member of C subfamily of ATP-binding cassette transporters, which pumps a variety of endogenous and exogenous organic anion compounds out of cells. Multidrug resistance protein 4 may be involved in the pathophysiological process of respiratory diseases, including lung cancer, bronchial asthma, pulmonary hypertension and so on. This paper reviews the research progress of the structure, biological function and role of multidrug resistance protein 4 in respiratory diseases.

关 键 词：呼吸系统疾病 多药耐药蛋白4 肺癌 支气管哮喘 肺动脉高压 

分 类 号：R56[医药卫生—呼吸系统]