氨甲环酸治疗初次单侧全膝关节置换术后出血疗效的Meta分析  

A Meta-analysis of the Efficacy of Tranexamic Acid in the Treatment of Bleeding during Initial Unilateral Total Knee Arthroplasty

作　　者：朱旺法 秦君[2] 贺小峰 李宏倬 Zhu Wangfa;Qin Jun;He Xiaofeng(Department of Hepatobiliary Surgery,Peace Hospital Affiliated to Changzhi Medical College)

机构地区：[1]长治医学院,046000 [2]长治医学院附属和平医院肝胆外科 [3]不详

出　　处：《长治医学院学报》2021年第2期145-149,共5页Journal of Changzhi Medical College

摘　　要：目的:比较氨甲环酸局部应用与静脉应用在初次单侧全膝关节置换术中的疗效。方法:通过检索PubMed、Cochrane Library、Embase、Web of Science英文数据库获取文献,采用Cochrane推荐的风险偏倚评估工具进行质量评价,采用Revman 5.3软件和Stata 12.0软件对效应指标进行统计分析。结果:共计28篇文献,33组随机对照实验,患者共计3423人,实验组1673人,对照组1750人,2组总出血量(MD=-24.41,95%CI=-63.12~14.30)、引流量(MD=-5.24,95%CI=-42.86~32.38)、血红蛋白下降值(MD=1.73,95%CI=-0.31~3.79)、输血率(MD=1.12,95%CI=0.89~1.42)、血栓相关并发症(MD=0.98,95%CI=0.58~1.65)比较差异均无统计学意义。结论:初次单侧全膝关节置换术中氨甲环酸局部与静脉两种给药方式疗效无差异。Objective:To compare the efficacy of local application and intravenous application of tranexamic acid in the initial unilateral total knee arthroplasty.Methods:Through searching PubMed,Cochrane Library,Embase and Web of Science to obtain literature,the risk bias assessment tool recommended by Cochrane was used for quality evaluation,and the Revman 5.3 software and Stata 12.0 software were used for statistical analysis of the effect indicators.Results:A total of 28 pieces of literature,33 groups of randomized controlled trials were included,and there were 3423 patients,1673 in the experimental group,1750 in the control group.There were no statistically significant differences in total bleeding(MD=-24.41,95%CI=-63.12~14.30),drainage volume(MD=-5.24,95%CI=-42.86~32.38),hemoglobin decrease value(MD=1.73,95%CI=-0.31~3.79),blood transfusion rate(MD=1.12,95%CI=0.89~1.42),thrombosis-related complications(MD=0.98,95%CI=0.58~1.65).Conclusion:In the initial unilateral total knee arthroplasty,the intravenous and intra-articular application of tranexamic acid has similar effectiveness and safety.

关 键 词：全膝关节置换术 氨甲环酸 局部应用 静脉应用 

分 类 号：R687[医药卫生—骨科学]