髋关节置换围术期局部灌注氨甲环酸对患者炎症因子的影响  

The Effect of Local Infusion of Tranexamic Acid during the Perioperative Period of Hip Replacement on Patients'Inflammatory Factors

作　　者：林四龙 潘宏[1] LIN Silong;PAN Hong(Department of Orthopedics,Anqing Hospital,Anhui Medical University,Anqing,Anhui Province,246000 China)

机构地区：[1]安徽医科大学附属安庆医院骨科,安徽安庆246000

出　　处：《中外医疗》2021年第10期79-81,共3页China & Foreign Medical Treatment

摘　　要：目的分析髋关节置换围术期局部灌注氨甲环酸对患者炎症因子的影响。方法方便选取2019年5月—2020年5月86例髋关节置换围术期患者作为研究对象,采用随机数表法分为对照组(42例)和观察组(44例)。对照组髋关节腔内给予生理盐水灌注,观察组给予局部灌注氨甲环酸,比较失血与输血情况、手术前后炎症因子水平、手术前后凝血功能。结果观察组术中出血量、术后引流量、隐性失血量、总失血量、输血量分别为(327.64±33.76)、(279.68±27.85)、(264.95±23.42)、(763.39±29.78)、(341.65±49.28)mL,对照组分别为(496.58±41.28)、(425.68±30.76)、(425.62±28.95)、(998.65±35.61)、(496.68±52.32)mL,观察组指标均低于对照组,差异有统计学意义(t=20.818、23.094、28.357、33.294、14.150,P=0.010、0.008、0.003、0.001、0.015);术前,两组CRP、IL-6水平相近,差异无统计学意义(P>0.05),术后,两组C反应蛋白(CRP)、白介素6(IL-6)水平均高于术前,差异有统计学意义(P<0.05),观察组术后CRP、IL-6水平低于对照组,差异有统计学意义(P<0.05);两组术前及术后血浆凝血酶原时间(PT)、血浆纤维蛋白原(FIB)、活化部分凝血活酶时间(APTT)水平均相近,差异无统计学意义(P>0.05)。结论髋关节置换围手术期局部灌注氨甲环酸能减少患者手术出血量及输血量,降低患者炎性因子水平,对患者凝血功能影响较小。Objective To analyze the effect of local infusion of tranexamic acid on patients'inflammatory factors during the perioperative period of hip replacement.Methods From May 2019 to May 2020,86 patients during the perioperative period of hip replacement were conveniently selected as the research objects,and they were divided into a control group(42 cases)and an observation group(44 cases)using a random number table method.The control group was given normal saline perfusion into the hip joint cavity,and the observation group was given local perfusion of tranexamic acid to compare blood loss and transfusion,the level of inflammatory factors before and after the operation,and the blood coagulation function before and after the operation.Results In the observation group,intraoperative blood loss,postoperative drainage,hidden blood loss,total blood loss,and blood transfusion were(327.64±33.76)mL,(279.68±27.85)mL,(264.95±23.42)mL,(763.39±29.78)mL,(341.65±49.28)mL,the control group was(496.58±41.28)mL,(425.68±30.76)mL,(425.62±28.95)mL,(998.65±35.61)mL,(496.68±52.32)mL,the indexes of the observation group were lower than those of the control group,and the difference was statistically significant(t=20.818,23.094,28.357,33.294,14.150,P=0.010,0.008,0.003,0.001,0.015);before operation,the levels of CRP and IL-6 in the two groups similar,the difference was not statistically significant(P>0.05).After the operation,the levels of C-reactive protein(CRP)and interleukin 6(IL-6)in the two groups were higher than those before the operation,and the difference was statistically significant(P<0.05).The postoperative CRP and IL-6 levels of the observation group were lower than those of the control group,the difference was statistically significant(P<0.05);the two groups of preoperative and postoperative plasma prothrombin time(PT),plasma fibrinogen(FIB),activated partial thromboplastin time(APTT)levels were similar,the difference was not statistically significant(P>0.05).Conclusion Local infusion of tranexamic acid during the peri

关 键 词：髋关节置换围手术期 氨甲环酸 炎症因子 

分 类 号：R4[医药卫生—临床医学]