阿托伐他汀联合缬沙坦在慢性肾炎中的效果与对C反应蛋白的影响  

The Effect of Atorvastatin Combined with Valsartan in Chronic Nephritis and Its Influence on C-reactive Protein

作　　者：肖振文[1] XIAO Zhenwen(Department of Nephrology,Jinan Third People's Hospital,Jinan,Shandong Province,250132 China)

机构地区：[1]济南市第三人民医院肾内科,山东济南250132

出　　处：《中外医疗》2021年第10期110-112,共3页China & Foreign Medical Treatment

摘　　要：目的慢性肾炎患者实施缬沙坦联合阿托伐他汀治疗的效果以及对C反应蛋白水平的影响分析。方法随机选取2018年7月—2019年7月在该院接受慢性肾炎治疗的100例患者,按照抽签法均分样本为双药结合组(n=50)和阿托伐他汀组(n=50),阿托伐他汀组选择阿托伐他汀进行治疗,双药结合组选择缬沙坦联合阿托伐他汀治疗,比较两组治疗前后的生化指标数据变化以及药物治疗效果。结果治疗前,双药结合组与阿托伐他汀组的24 h尿蛋白定量、血清尿素氮、血肌酐、肾小球滤过率、C反应蛋白、收缩压以及舒张压水平差异无统计学意义(P>0.05);治疗后,双药结合组的24 h尿蛋白定量、血清尿素氮、血肌酐、肾小球滤过率、C反应蛋白、收缩压以及舒张压水平均好于阿托伐他汀组,差异有统计学意义(P<0.05);双药结合组药物治疗总有效率(96.00%)优于阿托伐他汀组(76.00%),差异有统计学意义(χ^(2)=8.305,P<0.05)。结论缬沙坦联合阿托伐他汀治疗慢性肾炎的效果十分显著,能有效改善患者的生化指标水平,调节C反应蛋白水平,促进患者康复,相比单一用药治疗的效果,缬沙坦联合阿托伐他汀治疗的效果更具有推广价值。Objective To analyze the effect of valsartan combined with atorvastatin on the level of C-reactive protein in patients with chronic nephritis.Methods Ranolomly selected 100 patients who were treated for chronic nephritis in the hospital from July 2018 to July 2019.According to the lottery method,the samples were divided into two-drug combination group(n=50)and atorvastatin group(n=50).The atorvastatin group was selected for treatment with atorvastatin,and the dual-drug combination group was treated with valsartan combined with atorvastatin.The changes in biochemical index data before and after treatment and the effect of drug treatment were compared between the two groups.Results Before treatment,there were no statistically significant differences in the 24-hour urine protein quantification,serum urea nitrogen,serum creatinine,glomerular filtration rate,C-reactive protein,systolic blood pressure,and diastolic blood pressure between the dual-drug combination group and the atorvastatin group,without statistical comparison value(P>0.05);after treatment,24 h urine protein quantification,serum urea nitrogen,serum creatinine,glomerular filtration rate,C-reactive protein,systolic blood pressure and diastolic blood pressure in the dual-drug combination group better than the atorvastatin group,the difference was statistically significant(P<0.05);the total effective rate of drug treatment in the dual-drug combination group(96.00%)was better than that of the atorvastatin group(76.00%),the difference was statistically significant(χ^(2)=8.305,P<0.05).Conclusion The effect of valsartan combined with atorvastatin in the treatment of chronic nephritis is very significant.It can effectively improve the patient's biochemical index level,regulate the level of C-reactive protein,and promote the recovery of the patient.Compared with the effect of single drug treatment,valsartan combined with atorvastatin treatment has more promotion value.

关 键 词：慢性肾炎 缬沙坦 阿托伐他汀 生化指标 C反应蛋白 临床疗效 

分 类 号：R692.3[医药卫生—泌尿科学]