基于细胞药代动力学的中西药相互作用研究新思路与新方法  

New Insight and New Methodology for Herb-Drug Interactions Based on Cellular Pharmacokinetics

作　　者：刘丹晨 周芳[1] 张经纬[1] 王广基[1] LIU Dan-chen;ZHOU Fang;ZHANG Jing-wei;WANG Guang-ji(Key Lab of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, 210009, China)

机构地区：[1]中国药科大学药物代谢动力学重点实验室,江苏南京210009

出　　处：《南京中医药大学学报》2021年第3期325-330,共6页Journal of Nanjing University of Traditional Chinese Medicine

基　　金：江苏省科技厅科技计划项目(BK20192005);深圳市三名工程项目(SZSM201801060);中国药科大学天然药物活性组分与药效国家重点实验室自主课题资助项目(SKLNMZZ202001)。

摘　　要：中西药联用已成为国内外临床治疗的普遍现象,但相关评判尚缺乏完备的科学数据支撑。传统的药物代谢动力学研究局限于血浆药物浓度,无法阐明药物在靶部位的代谢处置过程,由此造成血浆药动-药效不相关的局限性。近年来,越来越多的研究着眼于定量分析药物经血液进入靶组织/靶细胞/亚细胞器的药代动力学过程,将药代动力学研究从“宏观”的血浆深入到“微观”的细胞层面。主要总结了基于细胞药代动力学的中西药相互作用研究新思路和新方法,为中西药联用增效减毒的机制研究和临床联合用药的应用提供依据。Herb and drug combination has become a common phenomenon on the clinical treatment,but its judgement criteria lacks a complete scientific basis.Traditional pharmacokinetic studies,restricted to plasma drug concentration,cannot clarify drug metabolism and disposition process in the target site,creating limitations such as irrelevant relationship between plasma PK and PD.In recent years,more and more studies focus on quantitative analysis of the process of drugs into the target area and cells through blood,which promotes pharmacokinetic researches from"macro"plasma into"micro"cells.Therefore,this paper mainly summarizes new technologies,new methods of herb-drug interaction researches based on the thought of cellular pharmacokinetics,as well as studies and clinical applications of herb-drug combination to improve effect and decrease toxicity.

关 键 词：中西药联用 药物相互作用 药物代谢动力学 细胞药代动力学 药物代谢酶 转运体 

分 类 号：R285.5[医药卫生—中药学]