冠状动脉内应用替罗非班在老年急性冠状动脉综合征急诊介入治疗中的效果分析  

Effect analysis of intracoronary application of tirofiban in emergency interventional therapy for elderly patients with acute coronary syndrome

作　　者：刘万莲 窦伟光 潘志祥 LIU Wan-lian;DOU Wei-guang;PAN Zhi-xiang(First Department of Cardiology,Qingzhou People’s Hospital,Qingzhou 262500,China)

机构地区：[1]青州市人民医院心内一科,262500

出　　处：《中国实用医药》2021年第13期14-17,共4页China Practical Medicine

摘　　要：目的分析冠状动脉内应用替罗非班在老年急性冠状动脉综合征急诊介入治疗中的临床效果。方法 88例老年急性冠状动脉综合征患者,随机分为对照组和观察组,各44例。所有患者均进行急诊介入治疗,在此基础上,对照组不使用替罗非班治疗,观察组冠状动脉内应用替罗非班治疗。观察比较两组患者TIMI血流分级及TIMI心肌灌注分级情况、心功能指标、并发症发生情况、心血管事件发生情况、不良反应发生情况。结果观察组TIMI血流分级Ⅲ级占比为93.18%, TIMI心肌灌注分级Ⅲ级占比为88.64%,均高于对照组的75.00%、63.64%,差异具有统计学意义(P<0.05)。观察组左室射血分数(LVEF)为(65.56±2.49)%,左室舒张末期内径(LVEDD)为(56.25±2.37)mm,二尖瓣舒张早期血流峰值(E/A)/心房收缩期血流峰值(A)值为(1.54±0.34),均大于对照组的(56.48±2.32)%、(43.81±2.48)mm、(0.37±0.32),差异具有统计学意义(P<0.05)。观察组并发症发生率、心血管事件发生率及不良反应发生率与对照组对比,差异均无统计学意义(P>0.05)。结论对老年急性冠状动脉综合征急诊介入治疗患者冠状动脉内应用替罗非班,可有效改善患者心功能情况及缺血心肌的血流灌注情况,降低心血管事件及并发症发生率,不良反应少,安全性高,值得借鉴。Objective To analyze the clinical effect of intracoronary application of tirofiban in emergency interventional therapy for elderly patients with acute coronary syndrome.Methods A total of 88 elderly patients with acute coronary syndrome were randomly divided into control group and observation group,with 44 cases in each group.All patients received emergency interventional therapy,on this basis,the control group was not treated with tirofiban,and the observation group was treated with intracoronary application of tirofiban.The TIMI flow grading,TIMI myocardial perfusion grading,cardiac function indicators,occurrence of complications,occurrence of cardiovascular events,and occurrence of adverse reactions were observed and compared between the two groups.Results The proportion of TIMI flow gradeⅢand TIMI myocardial perfusion gradeⅢof the observation group were 93.18%and 88.64%,which were higher than 75.00%and 63.64%of the control group,and the difference was statistically significant(P<0.05).The left ventricular ejection fraction(LVEF)(65.56±2.49)%,left ventricular end diastolic diameter(LVEDD)(56.25±2.37)mm and peak mitral flow velocity in early diastole to that during atrial contraction(E/A)(1.54±0.34)of the observation group were greater than(56.48±2.32)%,(43.81±2.48)mm and(0.37±0.32)of the control group,and the difference was statistically significant(P<0.05).The incidence of complications,cardiovascular events and adverse events of the observation group had no statistically significant difference compared with those of the control group(P>0.05).Conclusion During emergency interventional therapy of elderly patients with acute coronary syndrome,intracoronary application of tirofibana can improve the cardiac function of the patients,improve the blood perfusion of ischemic myocardium,lower incidence of cardiovascular events and complications with fewer adverse reactions and high safety.It is worthy of reference.

关 键 词：老年急性冠状动脉综合征 急诊介入 冠状动脉 替罗非班 

分 类 号：R541.4[医药卫生—心血管疾病]