血栓性疾病患者进行血浆D-二聚体检测的临床意义探讨  

Investigation on the clinical significance of plasma D-dimer detection in patients with thrombotic diseases

作　　者：张娟 ZHANG Juan(Fushun Third Hospital,Fushun 113004,China)

机构地区：[1]辽宁省抚顺市第三医院,113004

出　　处：《中国实用医药》2021年第13期43-45,共3页China Practical Medicine

摘　　要：目的探讨对血栓性疾病患者进行血浆D-二聚体检测的临床意义。方法选择90例血栓性疾病患者作为观察组,同期50例体检健康者作为对照组。两组均进行血浆D-二聚体检测。对比两组血浆D-二聚体水平及阳性率;对比观察组中不同血栓性疾病患者的血浆D-二聚体水平及阳性率。结果观察组患者血浆D-二聚体水平为(789.93±87.14)ng/ml,高于对照组的(174.01±67.49)ng/ml,差异具有统计学意义(P<0.05);观察组患者血浆D-二聚体阳性率为60.0%,高于对照组的2.0%,差异具有统计学意义(P<0.05)。下肢深静脉血栓、急性肺栓塞患者血浆D-二聚体水平及阳性率明显高于急性心肌梗死、冠心病、急性脑梗死、陈旧性脑梗死,差异具有统计学意义(P<0.05);急性心肌梗死、急性脑梗死患者血浆D-二聚体水平明显高于冠心病、陈旧性脑梗死,差异具有统计学意义(P<0.05)。结论血栓性疾病患者血浆D-二聚体水平明显高于健康人, D-二聚体是血栓性疾病的特异性指标,对血栓性疾病的诊断、治疗具有重要意义。Objective To discuss the clinical significance of plasma D-dimer detection in patients with thrombotic diseases.Methods There were 90 patients with thrombotic disease selected as the observation group,and concurrent 50 healthy subjects as the control group.Both groups received plasma D-dimer detection.Comparison was made on D-dimer level and positive rate between the two groups,and plasma D-dimer levels and positive rates of patients with different thrombotic diseases in the observation group.Results The plasma D-dimer level(789.93±87.14)ng/ml of the observation group was higher than(174.01±67.49)ng/ml of the control group,and the difference was statistically significant(P<0.05).The positive rate of plasma D-dimer of the observation group was 60.0%,which was higher than 2.0%of the control group,and the difference was statistically significant(P<0.05).The plasma D-dimer levels and positive rates of patients with deep vein thrombosis and acute pulmonary embolism were obviously higher than those patients with acute myocardial infarction,coronary heart disease,acute cerebral infarction and old cerebral infarction,and the difference was statistically significant(P<0.05).The plasma D-dimer levels and positive rates of patients with acute myocardial infarction and acute cerebral infarction were obviously higher than those patients with coronary heart disease and old cerebral infarction,and the difference was statistically significant(P<0.05).Conclusion The plasma D-dimer level of patients with thrombotic disease is obviously higher than that of healthy person.D-dimer is a specific indicator of thrombotic diseases,which is of great significance for the diagnosis and treatment of thrombotic diseases.

关 键 词：血栓性疾病 D-二聚体 临床意义 

分 类 号：R543[医药卫生—心血管疾病]