上皮源性细胞因子白细胞介素25、白细胞介素33和胸腺基质淋巴细胞生成素在统一气道疾病中的作用及联系  

Role of epithelial-derived cytokines IL-25,IL-33 and TSLP in united airway diseases and their relationships

作　　者：张安琪 李慧军[1] ZHANG Anqi;LI Huijun(The First Affiliated Hospital of Harbin Medical University,Harbin 150001,Heilongjiang Province,China)

机构地区：[1]哈尔滨医科大学附属第一医院,黑龙江哈尔滨150001

出　　处：《解放军医学院学报》2021年第2期224-228,共5页Academic Journal of Chinese PLA Medical School

基　　金：黑龙江省卫生计生委科研课题(LBH-Z18130)。

摘　　要：在“统一气道疾病”的概念中,呼吸道作为单一的器官,是抵御各种感染性病原体、过敏原和外界侵害的第一道防线,呼吸道上皮在免疫监测和调节中起着至关重要的作用。目前普遍认为有几种上皮源性细胞因子,即白细胞介素25(interleukin-25,IL-25)、白细胞介素33(interleukin-33,IL-33)和胸腺基质淋巴细胞生成素(thymic stromal lymphopoietin,TSLP)是变应性鼻炎(allergic rhinitis,AR)、慢性鼻窦炎(chronic rhinosinusitis,CRS)和哮喘发病机制中关键的调节因子,它们主要对Th2型免疫反应起到强大的推动作用,并可以将天然免疫和获得性免疫联系起来。此外,在统一气道疾病中还可能存在上皮细胞结构和功能轴。本文对这三种上皮源性细胞因子在呼吸道疾病发病中的作用及相关性进行综述,以期进一步了解统一气道疾病的发病机制。On the concept of‘united airway diseases’,the airway is a single organ wherein upper and lower airway diseases are commonly comorbid.The airway plays a vital role in immune surveillance and modulation as the firstline of defense to various infective pathogens,allergens and physical insults.Recently,there is a common hypothesis emphasizing epithelium-derived cytokines,namely IL-25,IL-33,and TSLP,as key regulatory factors that link in immune-pathogenic mechanisms of allergic rhinitis(AR),chronic rhinosinusitis(CRS),and asthma,mainly involving in type 2 inflammatory responses and linking innate and adaptive immunities.Here,we review the role and association of these three epigenetic cytokines in respiratory diseases,with a view to further understand the mechanism of the united airway diseases.

关 键 词：白细胞介素25 白细胞介素33 胸腺基质淋巴细胞生成素 统一气道疾病 

分 类 号：R562.25[医药卫生—呼吸系统]