成年型烟雾病患者血清陷窝蛋白-1水平检测及临床意义  

Detection and Clinical Significance of Serum Caveolin1 Level in Adult Patients with Moyamoya Disease

作　　者：王卫国 张颖 宋晓伟 WANG Wei-guo;ZHANG Ying;SONG Xiao-wei(Shaanxi Rehabilitation Hospital,Xi’an 710065,China;Respiratory Medicine Department,Yulin Traditional Chinese Medicine Hospital,Shaanxi Yulin 719000,China)

机构地区：[1]陕西省康复医院,西安710065 [2]榆林市中医医院呼吸内科,陕西榆林719000

出　　处：《现代检验医学杂志》2021年第3期100-102,共3页Journal of Modern Laboratory Medicine

摘　　要：目的探讨成年型烟雾病(moyamoya disease,MMD)血清陷窝蛋白-1(caveolin1,Cav1)的水平检测及临床意义。方法选择陕西省康复医院2016年1月~2019年12月收治的脑血管造影确诊的46例MMD患者为MMD组,另选择同期该院体检健康者50例作为对照组。采用酶联免疫吸附法(ELISA)检测血清中Cav1的水平。结果对照组血清中Cav1水平为0.46(0.28,0.61)ng/ml,MMD组血清中Cav1水平为0.86(0.34,1.29)ng/ml,MMD组血清中Cav1水平高于对照组,其差异具有统计学意义(Z=3.220,P=0.001)。MMD组患者不同首发症状的Cav1水平差异具有统计学意义,首发症状是脑出血的Cav1水平高于脑缺血的Cav1水平,差异具有统计学意义(t=2.803,P=0.043)。结论成年型MMD患者血清中Cav1水平高于健康人群,且与MMD患者的首发症状有关,其可用于MMD潜在生物学标记物的进一步研究。Objective To investigate the expression level and clinical significance of serum caveolin1(Cav1)in patients with moyamoya disease(MMD).Methods Forty-six MMD patients admitted to Shaanxi Rehabilitation Hospital from January 2016 to December 2019 and confirmed by cerebral angiography were selected as the MMD group,and 50 healthy patients in their hospital during the same period were selected as the control group.The level of Cav1 in serum was detected by Enzyme-linked Immunosorbent Assay(ELISA).The serum level of Cav1 in the two groups was compared.Results The serum level of Cav1 in the control group was 0.46(0.28,0.61)ng/ml,and that in the MMD group was 0.86(0.34,1.29)ng/ml.The serum level of Cav1 in the MMD group was higher than that in the control group,with statistically significant differences(Z=3.220,P=0.001).Cav1 levels of patients with different initial symptoms in the MMD group showed statistically significant differences,and Cav1 levels of patients with initial symptoms of cerebral hemorrhage were higher than those with cerebral ischemia(t=2.803,P=0.043).Conclusion The level of Cav1 in the serum of adult MMD patients is higher than that of healthy people and is related to the first symptoms of MMD patients,which can be used as a potential biological marker of MMD for further study.

关 键 词：烟雾病 陷窝蛋白-1 临床特征 

分 类 号：R543.4[医药卫生—心血管疾病] R392.11[医药卫生—内科学]