粪便微生物移植对仔猪肠道屏障功能的影响及作用机制进展  

Effects and Mechanism of Faecal Microbiota Transplantation on Intestinal Barrier Function in Piglets

作　　者：陈佳琦 张晓迪[2] 顾招兵[1] 吕龙宝[2] 吴东旺[1] 王荣蛟 毛华明[1] CHEN Jiaqi;ZHANG Xiaodi;GU Zhaobing;Lü Longbao;WU Dongwang;WANG Rongjiao;MAO Huaming(Key Laboratory of Animal Nutrition and Feed Science,Yunnan Agricultural University,Kumming 650201,China;Kunming Institute of Zoology,Chinese Academy of Sciences,Kumming 650223,China)

机构地区：[1]云南农业大学动物营养与饲料科学重点实验室,昆明650201 [2]中国科学院昆明动物研究所,昆明650223

出　　处：《畜牧兽医学报》2021年第5期1195-1207,共13页ACTA VETERINARIA ET ZOOTECHNICA SINICA

摘　　要：肠道屏障是抵御感染的重要防线。由肠道内微生物失调,屏障功能受损引起的仔猪腹泻给养猪业带来巨大损失。粪便微生物群移植在多种与肠道菌群相关的肠道疾病中显示出独特优势,被引入到操控仔猪肠道微生物以改善屏障功能的探索性研究中。本文介绍了肠道屏障的结构和功能,归纳了粪便微生物移植对仔猪肠道屏障的作用,并就可能的机制进行了探讨,以期为本领域的研究提供参考。The intestinal barrier is an important defense against infection.Diarrhea in piglets,mainly caused by intestinal biological imbalance and damage of barrier function,has brought extreme losses to the porcine industry.Due to the unique advantages in various intestinal diseases related to intestinal microbiota,faecal microbiota transplantation has been introduced into exploratory researches on the improvement of the intestinal barrier function in piglets as a new microbiota manipulation strategy.This article reviews the structures and functions of the intestinal barrier and the effects of faecal microbiota transplantation on it in piglets,then discusses the possible inner mechanisms,with the expectation to provide some references in this field.

关 键 词：粪便微生物移植 仔猪 肠道屏障功能 机制 微生物群落 

分 类 号：S854.5[农业科学—临床兽医学] S852.6[农业科学—兽医学]