祛风清热饮对于慢性荨麻疹患者外周血白细胞PI3K-Akt、NF-κB的mRNA含量影响  

Effect of Qufeng Qingre Decoction on PI3K-Akt and NF-κB mRNA Levels in Peripheral Blood Leukocytes of Patients with Chronic Urticaria

作　　者：刘海琴[1] 赵婧 LIU Hai-qin;ZHAO Jing(Nantong Disease Control and Prevention Center,Nantong Jiangsu 226007;The Third People′s Hospital of Nantong,Nantong Jiangsu 226007)

机构地区：[1]江苏省南通市疾病预防控制中心,江苏南通226007 [2]江苏省南通市第三人民医院,江苏南通226007

出　　处：《世界中西医结合杂志》2021年第3期509-513,共5页World Journal of Integrated Traditional and Western Medicine

基　　金：卫健委青年科研基金项目(WKZL2018082)。

摘　　要：目的探讨祛风清热饮对慢性荨麻疹患者的临床疗效及对外周血白细胞淋巴细胞磷酸肌醇-3激酶-蛋白激酶B(Phosphoinositide-3 kinase-protein kinase B,PI3K-Akt)、核因子κB(Nuclear factorκB,NF-κB)的mRNA含量的影响。方法选择2017年6月—2019年1月期间的慢性荨麻疹患者86例作为对象,随机分为对照组和治疗组,每组43例。对照组采用西替利嗪治疗,治疗组采用祛风清热饮治疗,两组均完成1个月治疗,疗程后完成12个月随访,比较两组患者临床症候积分、外周血白细胞中的PI3K-Akt、NF-κB的mRNA含量、炎症因子水平、药物安全性及治疗后复发率。结果两组患者治疗1个月后瘙痒程度、风团数目、风团最大直径、风团发作次数、风团持续时间评分均低于治疗前(P<0.05);且治疗组治疗1个月后瘙痒程度、风团数目、风团最大直径、风团发作次数、风团持续时间评分均低于对照组(P<0.05)。两组患者治疗1个月后PI3K-Akt、NF-κB的mRNA含量水平均低于治疗前(P<0.05);治疗组治疗1个月后PI3K-Akt、NF-κB的mRNA含量与对照组比较差异无统计学意义(P> 0.05)。两组患者治疗1个月后IL-4、IL-17水平降低,IL-23、IL-33水平升高与治疗前比较,差异有统计学意义(P<0.05);且治疗组治疗1个月后IL-4、IL-17水平低于对照组,IL-23、IL-33水平高于对照组,两组比较差异有统计学意义(P<0.05)。两组患者治疗过程中安全性及疗程后1个月复发率比较差异无统计学意义(P> 0.05);治疗组治疗6、12个月后复发率低于对照组(P<0.05)。结论祛风清热饮用于慢性荨麻疹患者的治疗中能改善患者症状及炎症因子水平,药物安全性较高,能降低治疗后复发率;但是,药物未改变外周血白细胞PI3K-Akt、NF-κB的mRNA含量,但可指导临床治疗,值得推广应用。Objective To explore the clinical efficacy of Qufeng Qingre Decoction in patients with chronic urticaria,as well as Phosphoinositide-3 kinase-protein kinase B(PI3 K-Akt) and nuclear factor κB in peripheral blood leukocyte lymphocytes(Nuclear factor κB,NF-κB) mRNA content.Methods A total of 86 patients with chronic urticaria from June 2017 to January 2019 were selected as subjects and randomly divided into control group and treatment group,with 43 cases in each group.The control group was treated with cetirizine,and the treatment group was treated with Qufeng Qingre Decoction.Both groups completed 1 month of treatment and completed 12 months of follow-up after the course of treatment.The two groups were compared with the clinical syndrome scores and the PI3 K-in peripheral blood leukocytes.Akt and NF-κB mRNA content,inflammatory factor levels,drug safety and recurrence rate after treatment.Results The pruritus degree,number of wind masses,maximum wind mass diameter,number of wind masses,and wind mass duration scores of the two groups of patients after-1 month of treatment were lower than before treatment(P <0.05);and the treatment group was treated for 1 month The degree of posterior itching,the number of wind masses,the maximum diameter of wind masses,the number of wind masses,and the scores of wind mass duration were all lower than those of the control group(P <0.05).The mRNA levels of PI3 K-Akt and NF-κB in the two groups of patients after 1 month of treatment were lower than before treatment(P <0.05);the mRNA levels of PI3 K-Akt and NF-κB in the treatment group were compared with those of the control group after 1 month of treatment The difference was not statistically significant(P> 0.05).After 1 month of treatment,the levels of IL-4 and IL-17 in the two groups decreased,and the levels of IL-23 and IL-33 increased compared with those before treatment.The difference was statistically significant(P <0.05);and the treatment group treated 1 After months,the levels of IL-4 and IL-17 were lower than those of

关 键 词：祛风清热饮 慢性荨麻疹 外周血白细胞 PI3K-AKT NF-ΚB 西替利嗪 炎症因子 

分 类 号：R758.24[医药卫生—皮肤病学与性病学]